Determination of carbon dioxide detection thresholds in trained rats

Steven Youngentob, David E. Hornung, Maxwell M. Mozell

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Concentration-response functions for the detection of CO2 were established for six rats. The animals were tested in a wind tunnel apparatus and trained using standard operant techniques and a discrete trials, go, no-go successive discrimination paradigm. The primary conclusion to be drawn from the performance measurements is that, at least under carefully controlled conditions, rats can detect physiologic concentrations of CO2 (0-4%). Minimum detectable concentrations fell within the range of 0.04-1.7% CO2. The concentration-response function describing the detectability of CO2 for the six rats was divided into an upper and lower limb at a concentration (5%) that was approximately equal to the end expiratory CO2 levels for the rat (4.88%). High levels of performance were observed for concentrations above this point, while those below it (0.02-2.5%) represented the dynamic range of detectability. Based on a 65% performance criterion, the average threshold performance for six rats was 0.52%. Possible interpretations of these data are discussed.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalPhysiology and Behavior
Volume49
Issue number1
DOIs
StatePublished - Jan 1 1991

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Carbon Dioxide
Lower Extremity

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Determination of carbon dioxide detection thresholds in trained rats. / Youngentob, Steven; Hornung, David E.; Mozell, Maxwell M.

In: Physiology and Behavior, Vol. 49, No. 1, 01.01.1991, p. 21-26.

Research output: Contribution to journalArticle

Youngentob, Steven ; Hornung, David E. ; Mozell, Maxwell M. / Determination of carbon dioxide detection thresholds in trained rats. In: Physiology and Behavior. 1991 ; Vol. 49, No. 1. pp. 21-26.
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