Determination of regional ventilation and perfusion in the lung using xenon and computed tomography

Thomas C. Kreck, Melissa A. Krueger, William A. Altemeier, Scott Sinclair, H. Thomas Robertson, Erin D. Shade, Jacob Hildebrandt, Wayne J.E. Lamm, David A. Frazer, Nayak L. Polissar, Michael P. Hlastala

Research output: Contribution to journalArticle

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Abstract

We propose a model to measure both regional ventilation (V̇) and perfusion (Q̇) in which the regional radiodensity (RD) in the lung during xenon (Xe) washin is a function of regional V̇ (increasing RD) and Q̇ (decreasing RD). We studied five anesthetized, paralyzed, mechanically ventilated, supine sheep. Four 2.5-mm-thick computed tomography (CT) images were simultaneously acquired immediately cephalad to the diaphragm at end inspiration for each breath during 3 min of Xe breathing. Observed changes in RD during Xe washin were used to determine regional V̇ and Q̇. For 16 mm3, Q̇ displayed more variance than V̇: the coefficient of variance of Q̇ (CVQ̇) = 1.58 ± 0.23, the CV of V̇ (CVv̇) = 0.46 ± 0.07, and the ratio of CVQ̇ to CVv̇ = 3.5 ± 1.1. CVQ̇ (1.21 ± 0.37) and the ratio of CVQ̇ to CVv̇ (2.4 ± 1.2) were smaller at 1,000-mm3 scale, but CVv̇ (0.53 ± 0.09) was not. V̇/Q̇ distributions also displayed scale dependence: log SD of V and log SD of Q were 0.79 ± 0.05 and 0.85 ± 0.10 for 16-mm3 and 0.69 ± 0.20 and 0.67 ± 0.10 for 1,000-mm3 regions of lung, respectively. V̇ and Q̇ measurements made with CT and Xe also demonstrate vertically oriented and isogravitational heterogeneity, which are described using other methodologies. Sequential images acquired by CT during Xe breathing can be used to determine both regional V̇ and Q̇ noninvasively with high spatial resolution.

Original languageEnglish (US)
Pages (from-to)1741-1749
Number of pages9
JournalJournal of Applied Physiology
Volume91
Issue number4
StatePublished - Oct 8 2001
Externally publishedYes

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Xenon
Ventilation
Perfusion
Tomography
Lung
Respiration
Diaphragm
Sheep

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Kreck, T. C., Krueger, M. A., Altemeier, W. A., Sinclair, S., Robertson, H. T., Shade, E. D., ... Hlastala, M. P. (2001). Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. Journal of Applied Physiology, 91(4), 1741-1749.

Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. / Kreck, Thomas C.; Krueger, Melissa A.; Altemeier, William A.; Sinclair, Scott; Robertson, H. Thomas; Shade, Erin D.; Hildebrandt, Jacob; Lamm, Wayne J.E.; Frazer, David A.; Polissar, Nayak L.; Hlastala, Michael P.

In: Journal of Applied Physiology, Vol. 91, No. 4, 08.10.2001, p. 1741-1749.

Research output: Contribution to journalArticle

Kreck, TC, Krueger, MA, Altemeier, WA, Sinclair, S, Robertson, HT, Shade, ED, Hildebrandt, J, Lamm, WJE, Frazer, DA, Polissar, NL & Hlastala, MP 2001, 'Determination of regional ventilation and perfusion in the lung using xenon and computed tomography', Journal of Applied Physiology, vol. 91, no. 4, pp. 1741-1749.
Kreck TC, Krueger MA, Altemeier WA, Sinclair S, Robertson HT, Shade ED et al. Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. Journal of Applied Physiology. 2001 Oct 8;91(4):1741-1749.
Kreck, Thomas C. ; Krueger, Melissa A. ; Altemeier, William A. ; Sinclair, Scott ; Robertson, H. Thomas ; Shade, Erin D. ; Hildebrandt, Jacob ; Lamm, Wayne J.E. ; Frazer, David A. ; Polissar, Nayak L. ; Hlastala, Michael P. / Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. In: Journal of Applied Physiology. 2001 ; Vol. 91, No. 4. pp. 1741-1749.
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abstract = "We propose a model to measure both regional ventilation (V̇) and perfusion (Q̇) in which the regional radiodensity (RD) in the lung during xenon (Xe) washin is a function of regional V̇ (increasing RD) and Q̇ (decreasing RD). We studied five anesthetized, paralyzed, mechanically ventilated, supine sheep. Four 2.5-mm-thick computed tomography (CT) images were simultaneously acquired immediately cephalad to the diaphragm at end inspiration for each breath during 3 min of Xe breathing. Observed changes in RD during Xe washin were used to determine regional V̇ and Q̇. For 16 mm3, Q̇ displayed more variance than V̇: the coefficient of variance of Q̇ (CVQ̇) = 1.58 ± 0.23, the CV of V̇ (CVv̇) = 0.46 ± 0.07, and the ratio of CVQ̇ to CVv̇ = 3.5 ± 1.1. CVQ̇ (1.21 ± 0.37) and the ratio of CVQ̇ to CVv̇ (2.4 ± 1.2) were smaller at 1,000-mm3 scale, but CVv̇ (0.53 ± 0.09) was not. V̇/Q̇ distributions also displayed scale dependence: log SD of V and log SD of Q were 0.79 ± 0.05 and 0.85 ± 0.10 for 16-mm3 and 0.69 ± 0.20 and 0.67 ± 0.10 for 1,000-mm3 regions of lung, respectively. V̇ and Q̇ measurements made with CT and Xe also demonstrate vertically oriented and isogravitational heterogeneity, which are described using other methodologies. Sequential images acquired by CT during Xe breathing can be used to determine both regional V̇ and Q̇ noninvasively with high spatial resolution.",
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AU - Robertson, H. Thomas

AU - Shade, Erin D.

AU - Hildebrandt, Jacob

AU - Lamm, Wayne J.E.

AU - Frazer, David A.

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