Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography

Khader M. Hasan, Amal Iftikhar, Arash Kamali, Larry A. Kramer, Manzar Ashtari, Paul T. Cirino, Andrew Papanicolaou, Jack M. Fletcher, Linda Ewing-Cobbs

Research output: Contribution to journalArticle

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Abstract

The human brain uncinate fasciculus (UF) is an important cortico-cortical white matter pathway that directly connects the frontal and temporal lobes, although there is a lack of conclusive support for its exact functional role. Using diffusion tensor tractography, we extracted the UF, calculated its volume and normalized it with respect to each subject's intracranial volume (ICV) and analyzed its corresponding DTI metrics bilaterally on a cohort of 108 right-handed children and adults aged 7-68 years. Results showed inverted U-shaped curves for fractional anisotropy (FA) with advancing age and U-shaped curves for radial and axial diffusivities reflecting white matter progressive and regressive myelination and coherence dynamics that continue into young adulthood. The mean FA values of the UF were significantly larger on the left side in children (p = 0.05), adults (p = 0.0012) and the entire sample (p = 0.0002). The FA leftward asymmetry (Left > Right) is shown to be due to increased leftward asymmetry in the axial diffusivity (p < 0.0001) and a lack of asymmetry (p > 0.23) for the radial diffusivity. This is the first study to provide baseline normative macro and microstructural age trajectories of the human UF across the lifespan. Results of this study may lend themselves to better understanding of UF role in future behavioral and clinical studies.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalBrain Research
Volume1276
DOIs
StatePublished - Jun 18 2009

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Diffusion Tensor Imaging
Anisotropy
Brain
Frontal Lobe
Temporal Lobe
White Matter

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Hasan, K. M., Iftikhar, A., Kamali, A., Kramer, L. A., Ashtari, M., Cirino, P. T., ... Ewing-Cobbs, L. (2009). Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography. Brain Research, 1276, 67-76. https://doi.org/10.1016/j.brainres.2009.04.025

Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography. / Hasan, Khader M.; Iftikhar, Amal; Kamali, Arash; Kramer, Larry A.; Ashtari, Manzar; Cirino, Paul T.; Papanicolaou, Andrew; Fletcher, Jack M.; Ewing-Cobbs, Linda.

In: Brain Research, Vol. 1276, 18.06.2009, p. 67-76.

Research output: Contribution to journalArticle

Hasan, KM, Iftikhar, A, Kamali, A, Kramer, LA, Ashtari, M, Cirino, PT, Papanicolaou, A, Fletcher, JM & Ewing-Cobbs, L 2009, 'Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography', Brain Research, vol. 1276, pp. 67-76. https://doi.org/10.1016/j.brainres.2009.04.025
Hasan, Khader M. ; Iftikhar, Amal ; Kamali, Arash ; Kramer, Larry A. ; Ashtari, Manzar ; Cirino, Paul T. ; Papanicolaou, Andrew ; Fletcher, Jack M. ; Ewing-Cobbs, Linda. / Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography. In: Brain Research. 2009 ; Vol. 1276. pp. 67-76.
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