Development and progression of secondary hyperparathyroidism in chronic kidney disease

Lessons from molecular genetics

William G. Goodman, Leigh Quarles

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as the major regulator of parathyroid gland function have important implications for understanding the pathogenesis and evolution of secondary hyperthyroidism in chronic kidney disease (CKD). Signaling through the CaSR has direct effects on three discrete components of parathyroid gland function, which include parathyroid hormone (PTH) secretion, PTH synthesis, and parathyroid gland hyperplasia. Disturbances in calcium and vitamin D metabolism that arise owing to CKD diminish the level of activation of the CaSR, leading to increases in PTH secretion, PTH synthesis, and parathyroid gland hyperplasia. Each represents a physiological adaptive response by the parathyroid glands to maintain plasma calcium homeostasis. Studies of genetically modified mice indicate that signal transduction via the CaSR is a key determinant of parathyroid cell proliferation and parathyroid gland hyperplasia. Because enlargement of the parathyroid glands has important implications for disease progression and disease severity, it is possible that clinical management strategies that maintain adequate calcium-dependent signaling through the CaSR will ultimately prove useful in diminishing parathyroid gland hyperplasia and in modifying disease progression.

Original languageEnglish (US)
Pages (from-to)276-288
Number of pages13
JournalKidney International
Volume74
Issue number3
DOIs
StatePublished - Jan 1 2008

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Secondary Hyperparathyroidism
Parathyroid Glands
Chronic Renal Insufficiency
Molecular Biology
Calcium-Sensing Receptors
Parathyroid Hormone
Hyperplasia
Disease Progression
Calcium
Calcium Signaling
Hyperthyroidism
Vitamin D
Signal Transduction
Homeostasis
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Development and progression of secondary hyperparathyroidism in chronic kidney disease : Lessons from molecular genetics. / Goodman, William G.; Quarles, Leigh.

In: Kidney International, Vol. 74, No. 3, 01.01.2008, p. 276-288.

Research output: Contribution to journalArticle

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