Development of platelet secretory granules

Sarah M. King, Guy Reed

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Platelet granule exocytosis plays a critical role in thrombosis and wound healing. Platelets have three major types of secretory granules that are defined by their unique molecular contents, kinetics of exocytosis and morphologies. Although the ontogeny of platelet granules is poorly understood, a convergence of new insights into megakaryocyte development, the molecular mechanisms of vesicle trafficking and the genetic basis of platelet granule defects, is beginning to define the cellular and molecular pathways responsible for platelet granule ontogeny.

Original languageEnglish (US)
Pages (from-to)293-302
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume13
Issue number4
DOIs
StatePublished - Jan 1 2002

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Secretory Vesicles
Blood Platelets
Exocytosis
Megakaryocytes
Wound Healing
Thrombosis

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

Development of platelet secretory granules. / King, Sarah M.; Reed, Guy.

In: Seminars in Cell and Developmental Biology, Vol. 13, No. 4, 01.01.2002, p. 293-302.

Research output: Contribution to journalArticle

King, Sarah M. ; Reed, Guy. / Development of platelet secretory granules. In: Seminars in Cell and Developmental Biology. 2002 ; Vol. 13, No. 4. pp. 293-302.
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