Development of W/O microemulsion for transdermal delivery of iodide ions

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The objective of this study was to develop a water-in-oil (w/o) microemulsion which can be utilized as a transdermal delivery for iodide ions. Several w/o microemulsion formulations were prepared utilizing Span 20, ethanol, Capryol 90®, and water. The selected formulations had 5%, 10%, 15%, 20%, and a maximum of 23% w/w water content. Potassium iodide (KI) was incorporated in all formulations at 5% w/v. Physicochemical characterizations were conducted to evaluate the structure and stability. These studies included: mean droplet size, pH, viscosity, conductivity, and chemical stability tests. In vitro human skin permeation studies were conducted to evaluate the diffusion of the iodide ion through human skin. The w/o microemulsion formulations were stable and compatible with iodide ions with water content ranging from 5% to 23% w/w. The addition of KI influenced the physicochemical properties of microemulsion as compared to blank microemulsion formulations. In vitro human skin permeation studies indicated that selected formulations improved iodide ion diffusion significantly as compared to control (KI solution; P value < 0.05). Iodide ions were entrapped within the aqueous core of w/o microemulsion. Span 20, ethanol and Capryol 90 protected the iodide ions against oxidation and formed a stable microemulsion. It is worth to note that according to Hofmeister series, iodide ions tend to lower the interfacial tension between water and oil and consequently enhance overall stability. This work illustrates that microemulsion system can be utilized as a vehicle for the transdermal administration of iodide.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalAAPS PharmSciTech
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2013

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Iodides
iodides
Ions
ions
Water
Oils
oils
skin (animal)
water
Skin
Ethanol
ethanol
Cutaneous Administration
potassium iodide
water content
Potassium Iodide
Surface Tension
droplet size
surface tension
Viscosity

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Development of W/O microemulsion for transdermal delivery of iodide ions. / Lou, Hao; Qiu, Ni; Herrington, Catherine; Helms, Richard; Almoazen, Hassan.

In: AAPS PharmSciTech, Vol. 14, No. 1, 01.01.2013, p. 168-176.

Research output: Contribution to journalArticle

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