Diagnosis and management of out-of-phase endometrial biopsies among patients receiving clomiphene citrate for ovulation induction

Jeffrey Keenan, C. M. Herbert, J. R. Bush, A. Colston Wentz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Eighty-seven patients who underwent a late secretory phase endometrial biopsy while taking clomiphene citrate (CC) for ovulation induction were studied. Of the endometrial biopsies, 21 (24%) showed an endometrium > 2 days out of phase (OOP) with respect to the subsequent menstrual cycle. All 87 patients were categorized by age, weight, CC dosage, and underlying disease entity. The patients then were evaluated by these categories in relation to the incidence of an OOP biopsy while taking CC. Patients with a diagnosis of hypothalamic amenorrhea were statistically more likely to have an OOP endometrium. No other subgroup showed an increased or decreased incidence of OOP biopsies. Conception and spontaneous abortion rates were similar among patients with in-phase biopsies and those with out-of-phase biopsies, which subsequently were corrected with further medical therapy. An aggressive approach to the diagnosis and treatment of luteal phase insufficiency in patients who receive CC for ovulation induction is recommended.

Original languageEnglish (US)
Pages (from-to)964-967
Number of pages4
JournalFertility and Sterility
Volume51
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Clomiphene
Ovulation Induction
Biopsy
Endometrium
Induced Abortion
Luteal Phase
Amenorrhea
Incidence
Spontaneous Abortion
Menstrual Cycle
Weights and Measures
Therapeutics

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

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Diagnosis and management of out-of-phase endometrial biopsies among patients receiving clomiphene citrate for ovulation induction. / Keenan, Jeffrey; Herbert, C. M.; Bush, J. R.; Colston Wentz, A.

In: Fertility and Sterility, Vol. 51, No. 6, 01.01.1989, p. 964-967.

Research output: Contribution to journalArticle

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