Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats

I. E. Hensley, J. E. Lawler, Ramin Alemzadeh, S. J. Holshouser

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To determine if the anorectic effects of the insulin antagonist diazoxide (DZ) are mediated by reduced central neuropeptide Y (NPY), female Zucker rats, given DZ (150 mg/kg/day) or placebo for about four weeks, were sacrificed following overnight fasting or free feeding. Several hypothalamic and extra-hypothalamic nuclei were extracted for NPY content. DZ reduced weight gain in obese rats and lowered glucose of lean and obese rats without affecting insulin. Contrary to the hypothesis, DZ increased NPY in hypothalamic nuclei of free fed lean and obese rats. DZ elevated hypothalamic NPY levels in fasted obese rats and had more diverse effects in extra-hypothalamic nuclei of lean rats.

Original languageEnglish (US)
Pages (from-to)899-908
Number of pages10
JournalPeptides
Volume22
Issue number6
DOIs
StatePublished - Jun 21 2001

Fingerprint

Diazoxide
Zucker Rats
Neuropeptide Y
Rats
Insulin Antagonists
Appetite Depressants
Weight Gain
Fasting
Placebos
Insulin
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats. / Hensley, I. E.; Lawler, J. E.; Alemzadeh, Ramin; Holshouser, S. J.

In: Peptides, Vol. 22, No. 6, 21.06.2001, p. 899-908.

Research output: Contribution to journalArticle

Hensley, I. E. ; Lawler, J. E. ; Alemzadeh, Ramin ; Holshouser, S. J. / Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats. In: Peptides. 2001 ; Vol. 22, No. 6. pp. 899-908.
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