Dielectrophoresis

A model to transport drugs directly into teeth

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The article describes an innovative delivery system based on the principles of dielectrophoresis to transport drugs directly into site-specific intraoral targets. The hypothesis that a drug can be driven into tooth enamel during the application of an applied electrical potential difference was tested by the authors in in vitro studies comparing dielectrophoresis to diffusion to transport carbamide peroxide and fluoride. The studies showed that these agents can be transported directly into teeth using an alternating current (AC) electric field more effectively than diffusion. It was found that a 20-min bleaching treatment on human teeth with dielectrophoresis increased carbamide peroxide absorption by 104% and, on average, improved the change in shade guide unit 14 times from 0.6 SGU to 9 SGU. After applying a 1.23% acidulated phosphate fluoride gel to bovine incisors for 20 min by dielectrophoresis or diffusion, analysis with wavelength dispersive spectrometry determined that dielectrophoresis doubled fluoride uptake in the superficial layers compared to diffusion, and drove the fluoride significantly deeper into enamel with an uptake 600% higher than diffusion at 50 μm depth. Finally, dielectrophoresis promises to be a viable model that can potentially be used clinically to deliver other targeted drugs of variable molecular weight and structure.

Original languageEnglish (US)
Pages (from-to)1311-1321
Number of pages11
JournalElectrophoresis
Volume33
Issue number8
DOIs
StatePublished - Apr 1 2012

Fingerprint

Electrophoresis
Tooth
Fluorides
Pharmaceutical Preparations
Dental Enamel
Acidulated Phosphate Fluoride
Tooth enamel
Incisor
Molecular Structure
Enamels
Bleaching
Spectrum Analysis
Spectrometry
Molecular structure
Molecular Weight
Gels
Molecular weight
Electric fields
Wavelength
carbamide peroxide

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry

Cite this

Dielectrophoresis : A model to transport drugs directly into teeth. / Ivanoff, Chris; Hottel, Timothy; Garcia-Godoy, Franklin.

In: Electrophoresis, Vol. 33, No. 8, 01.04.2012, p. 1311-1321.

Research output: Contribution to journalArticle

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