Diet-induced ketosis improves cognitive performance in aged rats

Kui Xu, Xiaoyan Sun, Bernadette O. Eroku, Constantinos P. Tsipis, Michelle Puchowicz, Joseph C. LaManna

Research output: Chapter in Book/Report/Conference proceedingConference contribution

25 Citations (Scopus)

Abstract

Aging is associated with increased susceptibility to hypoxic/ischemic insult and declines in behavioral function which may be due to attenuated adaptive/ defense responses. We investigated if diet-induced ketosis would improve behavioral performance in the aged rats. Fischer 344 rats (3- and 22-month-old) were fed standard (STD) or ketogenic (KG) diet for 3 weeks and then exposed to hypobaric hypoxia. Cognitive function wasmeasured using the T-maze and object recognition tests. Motor function was measured using the inclined-screen test. Results showed that KG diet significantly increased blood ketone levels in both young and old rats. In the aged rats, the KG diet improved cognitive performance under normoxic and hypoxic conditions; while motor performance remained unchanged. Capillary density and HIF-1a levels were elevated in the aged ketotic group independent of hypoxic challenge. These data suggest that diet-induced ketosis may be beneficial in the treatment of neurodegenerative conditions.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXI
EditorsEiji Takahashi, Duane Bruley
Pages71-75
Number of pages5
DOIs
StatePublished - Dec 1 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume662
ISSN (Print)0065-2598

Fingerprint

Ketogenic Diet
Ketosis
Nutrition
Rats
Diet
Inbred F344 Rats
Ketones
Cognition
Object recognition
Blood
Aging of materials
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Xu, K., Sun, X., Eroku, B. O., Tsipis, C. P., Puchowicz, M., & LaManna, J. C. (2010). Diet-induced ketosis improves cognitive performance in aged rats. In E. Takahashi, & D. Bruley (Eds.), Oxygen Transport to Tissue XXXI (pp. 71-75). (Advances in Experimental Medicine and Biology; Vol. 662). https://doi.org/10.1007/978-1-4419-1241-1_9

Diet-induced ketosis improves cognitive performance in aged rats. / Xu, Kui; Sun, Xiaoyan; Eroku, Bernadette O.; Tsipis, Constantinos P.; Puchowicz, Michelle; LaManna, Joseph C.

Oxygen Transport to Tissue XXXI. ed. / Eiji Takahashi; Duane Bruley. 2010. p. 71-75 (Advances in Experimental Medicine and Biology; Vol. 662).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xu, K, Sun, X, Eroku, BO, Tsipis, CP, Puchowicz, M & LaManna, JC 2010, Diet-induced ketosis improves cognitive performance in aged rats. in E Takahashi & D Bruley (eds), Oxygen Transport to Tissue XXXI. Advances in Experimental Medicine and Biology, vol. 662, pp. 71-75. https://doi.org/10.1007/978-1-4419-1241-1_9
Xu K, Sun X, Eroku BO, Tsipis CP, Puchowicz M, LaManna JC. Diet-induced ketosis improves cognitive performance in aged rats. In Takahashi E, Bruley D, editors, Oxygen Transport to Tissue XXXI. 2010. p. 71-75. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1241-1_9
Xu, Kui ; Sun, Xiaoyan ; Eroku, Bernadette O. ; Tsipis, Constantinos P. ; Puchowicz, Michelle ; LaManna, Joseph C. / Diet-induced ketosis improves cognitive performance in aged rats. Oxygen Transport to Tissue XXXI. editor / Eiji Takahashi ; Duane Bruley. 2010. pp. 71-75 (Advances in Experimental Medicine and Biology).
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