Dietary carotenoid intake and colorectal cancer risk

Paul Terry, Meera Jain, Anthony B. Miller, Geoffrey R. Howe, Thomas E. Rohan

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than β-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of β-carotene, α-carotene, lycopene, lutein, and β-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalNutrition and Cancer
Volume42
Issue number2
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Carotenoids
Colorectal Neoplasms
Cohort Studies
Lutein
Phytochemicals
Folic Acid
Vegetables
Case-Control Studies
Fruit
Breast
Body Mass Index
Smoking
Fats
Body Weight
Alcohols
Prospective Studies
Food
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Terry, P., Jain, M., Miller, A. B., Howe, G. R., & Rohan, T. E. (2002). Dietary carotenoid intake and colorectal cancer risk. Nutrition and Cancer, 42(2), 167-172. https://doi.org/10.1207/S15327914NC422_3

Dietary carotenoid intake and colorectal cancer risk. / Terry, Paul; Jain, Meera; Miller, Anthony B.; Howe, Geoffrey R.; Rohan, Thomas E.

In: Nutrition and Cancer, Vol. 42, No. 2, 01.01.2002, p. 167-172.

Research output: Contribution to journalArticle

Terry, P, Jain, M, Miller, AB, Howe, GR & Rohan, TE 2002, 'Dietary carotenoid intake and colorectal cancer risk', Nutrition and Cancer, vol. 42, no. 2, pp. 167-172. https://doi.org/10.1207/S15327914NC422_3
Terry, Paul ; Jain, Meera ; Miller, Anthony B. ; Howe, Geoffrey R. ; Rohan, Thomas E. / Dietary carotenoid intake and colorectal cancer risk. In: Nutrition and Cancer. 2002 ; Vol. 42, No. 2. pp. 167-172.
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