Dietary oligofructose and inulin modulate immune functions in mice

K. A. Kelly-Quagliana, P. D. Nelson, Randal Buddington

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Host defense functions are responsive to diet composition. Since inulin and oligofructose increase resistance to health challenges, selected systemic immune variables were measured in B6C3F1 mice fed diets containing 10g/100g cellulose (C) or with cellulose replaced entirely with oligofructose (OF) or inulin (I), or partially (2.5 g) with oligofructose (C-OF). White blood cell counts for all groups were within normal ranges, but were 100% higher (P < 0.05) in C mice compared to mice fed fructan-containing diets, which had similar counts. Spleen mass, CD4/CD8 and T/B ratios from suspensions of spleen and thymus, and fecal IgA concentrations did not differ among groups. OF and I mice had higher natural killer cell activity of splenocytes and greater phagocytic activity of peritoneal macrophages. Apparently oligofructose and inulin do not elicit an increase or redistribution of the examined lymphocyte populations (CD4/CD8 and T/B), but up-regulate macrophage-dependent (T-helper 1 type) immune responses in a dose-dependent manner.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
JournalNutrition Research
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

Fingerprint

Inulin
Diet
Cellulose
Spleen
Fructans
Peritoneal Macrophages
Leukocyte Count
Natural Killer Cells
Immunoglobulin A
Thymus Gland
oligofructose
Suspensions
Reference Values
Up-Regulation
Macrophages
Lymphocytes
Health
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Dietary oligofructose and inulin modulate immune functions in mice. / Kelly-Quagliana, K. A.; Nelson, P. D.; Buddington, Randal.

In: Nutrition Research, Vol. 23, No. 2, 01.02.2003, p. 257-267.

Research output: Contribution to journalArticle

Kelly-Quagliana, K. A. ; Nelson, P. D. ; Buddington, Randal. / Dietary oligofructose and inulin modulate immune functions in mice. In: Nutrition Research. 2003 ; Vol. 23, No. 2. pp. 257-267.
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