Dietary patterns, insulin sensitivity and inflammation in older adults

A. L. Anderson, T. B. Harris, Frances Tylavsky, S. E. Perry, D. K. Houston, J. S. Lee, A. M. Kanaya, N. R. Sahyoun

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background/Objectives: Several studies have linked dietary patterns to insulin sensitivity and systemic inflammation, which affect risk of multiple chronic diseases. The purpose of this study was to investigate the dietary patterns of a cohort of older adults, and to examine relationships of dietary patterns with markers of insulin sensitivity and systemic inflammation. Subjects/Methods: The Health, Aging and Body Composition (Health ABC) Study is a prospective cohort study of 3075 older adults. In Health ABC, multiple indicators of glucose metabolism and systemic inflammation were assessed. Food intake was estimated with a modified Block food frequency questionnaire. In this study, dietary patterns of 1751 participants with complete data were derived by cluster analysis. Results: Six clusters were identified, including a 'healthy foods' cluster, characterized by higher intake of low-fat dairy products, fruit, whole grains, poultry, fish and vegetables. In the main analysis, the healthy foods cluster had significantly lower fasting insulin and homeostasis model assessment of insulin resistance values than the 'breakfast' cereal and 'high-fat dairy products' clusters, and lower fasting glucose than the high-fat dairy products cluster (P≤0.05). No differences were found in 2-h glucose. With respect to inflammation, the healthy foods cluster had lower interleukin-6 than the sweets and desserts and 'high-fat dairy products' clusters, and no differences were seen in C-reactive protein or tumor necrosis factor-α. Conclusions: A dietary pattern high in low-fat dairy products, fruit, whole grains, poultry, fish and vegetables may be associated with greater insulin sensitivity and lower systemic inflammation in older adults.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number1
DOIs
StatePublished - Jan 1 2012

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Dairy Products
Insulin Resistance
Fats
Inflammation
Food
Poultry
Body Composition
Glucose
Vegetables
Fasting
Fruit
Fishes
Breakfast
Health
C-Reactive Protein
Cluster Analysis
Interleukin-6
Homeostasis
Cohort Studies
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Anderson, A. L., Harris, T. B., Tylavsky, F., Perry, S. E., Houston, D. K., Lee, J. S., ... Sahyoun, N. R. (2012). Dietary patterns, insulin sensitivity and inflammation in older adults. European Journal of Clinical Nutrition, 66(1), 18-24. https://doi.org/10.1038/ejcn.2011.162

Dietary patterns, insulin sensitivity and inflammation in older adults. / Anderson, A. L.; Harris, T. B.; Tylavsky, Frances; Perry, S. E.; Houston, D. K.; Lee, J. S.; Kanaya, A. M.; Sahyoun, N. R.

In: European Journal of Clinical Nutrition, Vol. 66, No. 1, 01.01.2012, p. 18-24.

Research output: Contribution to journalArticle

Anderson, AL, Harris, TB, Tylavsky, F, Perry, SE, Houston, DK, Lee, JS, Kanaya, AM & Sahyoun, NR 2012, 'Dietary patterns, insulin sensitivity and inflammation in older adults', European Journal of Clinical Nutrition, vol. 66, no. 1, pp. 18-24. https://doi.org/10.1038/ejcn.2011.162
Anderson, A. L. ; Harris, T. B. ; Tylavsky, Frances ; Perry, S. E. ; Houston, D. K. ; Lee, J. S. ; Kanaya, A. M. ; Sahyoun, N. R. / Dietary patterns, insulin sensitivity and inflammation in older adults. In: European Journal of Clinical Nutrition. 2012 ; Vol. 66, No. 1. pp. 18-24.
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