Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults

The Health, Aging, and Body Composition (Health ABC) Study

Amely M. Verreijen, Mariëlle F. Engberink, Denise K. Houston, Ingeborg A. Brouwer, Peggy M. Cawthon, Ann B. Newman, Frances Tylavsky, Tamara B. Harris, Peter J.M. Weijs, Marjolein Visser

Research output: Contribution to journalArticle

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Abstract

Background A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia. Objectives We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561). Methods Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass. Results Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95% CI) 5-y change in muscle CSA was-9.8 (-10.6,-8.9) cm 2. No association was observed between energy-adjusted total (β =-0.00; 95% CI:-0.06, 0.06 cm 2; P = 0.982), animal (β =-0.00; 95% CI:-0.06, 0.05 cm 2; P = 0.923), or plant (β = +0.07; 95% CI:-0.06, 0.21 cm 2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders. Conclusions This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

Original languageEnglish (US)
Pages (from-to)544-553
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume109
Issue number3
DOIs
StatePublished - Mar 1 2019

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Dietary Proteins
Thigh
Body Composition
Tomography
Muscles
Health
Vegetable Proteins
Proteins
Sarcopenia
Muscle Proteins
Linear Models
Cohort Studies
Fats
Regression Analysis
Prospective Studies
Food
Research

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults : The Health, Aging, and Body Composition (Health ABC) Study. / Verreijen, Amely M.; Engberink, Mariëlle F.; Houston, Denise K.; Brouwer, Ingeborg A.; Cawthon, Peggy M.; Newman, Ann B.; Tylavsky, Frances; Harris, Tamara B.; Weijs, Peter J.M.; Visser, Marjolein.

In: American Journal of Clinical Nutrition, Vol. 109, No. 3, 01.03.2019, p. 544-553.

Research output: Contribution to journalArticle

Verreijen, Amely M. ; Engberink, Mariëlle F. ; Houston, Denise K. ; Brouwer, Ingeborg A. ; Cawthon, Peggy M. ; Newman, Ann B. ; Tylavsky, Frances ; Harris, Tamara B. ; Weijs, Peter J.M. ; Visser, Marjolein. / Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults : The Health, Aging, and Body Composition (Health ABC) Study. In: American Journal of Clinical Nutrition. 2019 ; Vol. 109, No. 3. pp. 544-553.
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title = "Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: The Health, Aging, and Body Composition (Health ABC) Study",
abstract = "Background A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia. Objectives We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561). Methods Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass. Results Mean (95{\%} CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95{\%} CI) 5-y change in muscle CSA was-9.8 (-10.6,-8.9) cm 2. No association was observed between energy-adjusted total (β =-0.00; 95{\%} CI:-0.06, 0.06 cm 2; P = 0.982), animal (β =-0.00; 95{\%} CI:-0.06, 0.05 cm 2; P = 0.923), or plant (β = +0.07; 95{\%} CI:-0.06, 0.21 cm 2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders. Conclusions This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.",
author = "Verreijen, {Amely M.} and Engberink, {Mari{\"e}lle F.} and Houston, {Denise K.} and Brouwer, {Ingeborg A.} and Cawthon, {Peggy M.} and Newman, {Ann B.} and Frances Tylavsky and Harris, {Tamara B.} and Weijs, {Peter J.M.} and Marjolein Visser",
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T1 - Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults

T2 - The Health, Aging, and Body Composition (Health ABC) Study

AU - Verreijen, Amely M.

AU - Engberink, Mariëlle F.

AU - Houston, Denise K.

AU - Brouwer, Ingeborg A.

AU - Cawthon, Peggy M.

AU - Newman, Ann B.

AU - Tylavsky, Frances

AU - Harris, Tamara B.

AU - Weijs, Peter J.M.

AU - Visser, Marjolein

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia. Objectives We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561). Methods Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass. Results Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95% CI) 5-y change in muscle CSA was-9.8 (-10.6,-8.9) cm 2. No association was observed between energy-adjusted total (β =-0.00; 95% CI:-0.06, 0.06 cm 2; P = 0.982), animal (β =-0.00; 95% CI:-0.06, 0.05 cm 2; P = 0.923), or plant (β = +0.07; 95% CI:-0.06, 0.21 cm 2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders. Conclusions This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

AB - Background A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia. Objectives We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561). Methods Protein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70-79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass. Results Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg-1 · d-1 and mean (95% CI) 5-y change in muscle CSA was-9.8 (-10.6,-8.9) cm 2. No association was observed between energy-adjusted total (β =-0.00; 95% CI:-0.06, 0.06 cm 2; P = 0.982), animal (β =-0.00; 95% CI:-0.06, 0.05 cm 2; P = 0.923), or plant (β = +0.07; 95% CI:-0.06, 0.21 cm 2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders. Conclusions This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

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