Dietary Quality and Ovarian Cancer Risk in African-American Women

Bo Qin, Patricia G. Moorman, Linda E. Kelemen, Anthony J. Alberg, Jill S. Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Paul Terry, Joellen M. Schildkraut, Elisa V. Bandera

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study evaluated 3 index-based dietary patterns - Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010 - in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders. We found that higher AHEI-2010 scores, but not HEI-2005 or HEI-2010 scores, were associated with lower risk of ovarian cancer (comparing the highest quartile (4th) vs. lowest (1st), odds ratio (OR) = 0.66, 95% confidence interval (CI): 0.45, 0.98; P for trend = 0.05). When stratified by menopausal status, no noteworthy associations were observed among premenopausal women. However, among postmenopausal women, greater adherence to HEI-2010 (quartile 4 vs. quartile 1, OR = 0.57, 95% CI: 0.36, 0.92; P for trend = 0.03) and AHEI-2010 (quartile 4 vs. quartile 1, OR = 0.49, 95% CI: 0.31, 0.78; P for trend = 0.01) were inversely associated with ovarian cancer. Our findings indicate that adherence to an overall healthy dietary pattern may reduce ovarian cancer risk in African-American women, and particularly among postmenopausal African-American women.

Original languageEnglish (US)
Pages (from-to)1281-1289
Number of pages9
JournalAmerican Journal of Epidemiology
Volume185
Issue number12
DOIs
StatePublished - Jun 15 2017

Fingerprint

African Americans
Ovarian Neoplasms
Odds Ratio
Confidence Intervals
Logistic Models
Healthy Diet
Epidemiology
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Qin, B., Moorman, P. G., Kelemen, L. E., Alberg, A. J., Barnholtz-Sloan, J. S., Bondy, M., ... Bandera, E. V. (2017). Dietary Quality and Ovarian Cancer Risk in African-American Women. American Journal of Epidemiology, 185(12), 1281-1289. https://doi.org/10.1093/aje/kwx022

Dietary Quality and Ovarian Cancer Risk in African-American Women. / Qin, Bo; Moorman, Patricia G.; Kelemen, Linda E.; Alberg, Anthony J.; Barnholtz-Sloan, Jill S.; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul; Schildkraut, Joellen M.; Bandera, Elisa V.

In: American Journal of Epidemiology, Vol. 185, No. 12, 15.06.2017, p. 1281-1289.

Research output: Contribution to journalArticle

Qin, B, Moorman, PG, Kelemen, LE, Alberg, AJ, Barnholtz-Sloan, JS, Bondy, M, Cote, ML, Funkhouser, E, Peters, ES, Schwartz, AG, Terry, P, Schildkraut, JM & Bandera, EV 2017, 'Dietary Quality and Ovarian Cancer Risk in African-American Women', American Journal of Epidemiology, vol. 185, no. 12, pp. 1281-1289. https://doi.org/10.1093/aje/kwx022
Qin B, Moorman PG, Kelemen LE, Alberg AJ, Barnholtz-Sloan JS, Bondy M et al. Dietary Quality and Ovarian Cancer Risk in African-American Women. American Journal of Epidemiology. 2017 Jun 15;185(12):1281-1289. https://doi.org/10.1093/aje/kwx022
Qin, Bo ; Moorman, Patricia G. ; Kelemen, Linda E. ; Alberg, Anthony J. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul ; Schildkraut, Joellen M. ; Bandera, Elisa V. / Dietary Quality and Ovarian Cancer Risk in African-American Women. In: American Journal of Epidemiology. 2017 ; Vol. 185, No. 12. pp. 1281-1289.
@article{21480a08094c47c4bffb747ceb325cfb,
title = "Dietary Quality and Ovarian Cancer Risk in African-American Women",
abstract = "This study evaluated 3 index-based dietary patterns - Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010 - in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95{\%} confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders. We found that higher AHEI-2010 scores, but not HEI-2005 or HEI-2010 scores, were associated with lower risk of ovarian cancer (comparing the highest quartile (4th) vs. lowest (1st), odds ratio (OR) = 0.66, 95{\%} confidence interval (CI): 0.45, 0.98; P for trend = 0.05). When stratified by menopausal status, no noteworthy associations were observed among premenopausal women. However, among postmenopausal women, greater adherence to HEI-2010 (quartile 4 vs. quartile 1, OR = 0.57, 95{\%} CI: 0.36, 0.92; P for trend = 0.03) and AHEI-2010 (quartile 4 vs. quartile 1, OR = 0.49, 95{\%} CI: 0.31, 0.78; P for trend = 0.01) were inversely associated with ovarian cancer. Our findings indicate that adherence to an overall healthy dietary pattern may reduce ovarian cancer risk in African-American women, and particularly among postmenopausal African-American women.",
author = "Bo Qin and Moorman, {Patricia G.} and Kelemen, {Linda E.} and Alberg, {Anthony J.} and Barnholtz-Sloan, {Jill S.} and Melissa Bondy and Cote, {Michele L.} and Ellen Funkhouser and Peters, {Edward S.} and Schwartz, {Ann G.} and Paul Terry and Schildkraut, {Joellen M.} and Bandera, {Elisa V.}",
year = "2017",
month = "6",
day = "15",
doi = "10.1093/aje/kwx022",
language = "English (US)",
volume = "185",
pages = "1281--1289",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Dietary Quality and Ovarian Cancer Risk in African-American Women

AU - Qin, Bo

AU - Moorman, Patricia G.

AU - Kelemen, Linda E.

AU - Alberg, Anthony J.

AU - Barnholtz-Sloan, Jill S.

AU - Bondy, Melissa

AU - Cote, Michele L.

AU - Funkhouser, Ellen

AU - Peters, Edward S.

AU - Schwartz, Ann G.

AU - Terry, Paul

AU - Schildkraut, Joellen M.

AU - Bandera, Elisa V.

PY - 2017/6/15

Y1 - 2017/6/15

N2 - This study evaluated 3 index-based dietary patterns - Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010 - in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders. We found that higher AHEI-2010 scores, but not HEI-2005 or HEI-2010 scores, were associated with lower risk of ovarian cancer (comparing the highest quartile (4th) vs. lowest (1st), odds ratio (OR) = 0.66, 95% confidence interval (CI): 0.45, 0.98; P for trend = 0.05). When stratified by menopausal status, no noteworthy associations were observed among premenopausal women. However, among postmenopausal women, greater adherence to HEI-2010 (quartile 4 vs. quartile 1, OR = 0.57, 95% CI: 0.36, 0.92; P for trend = 0.03) and AHEI-2010 (quartile 4 vs. quartile 1, OR = 0.49, 95% CI: 0.31, 0.78; P for trend = 0.01) were inversely associated with ovarian cancer. Our findings indicate that adherence to an overall healthy dietary pattern may reduce ovarian cancer risk in African-American women, and particularly among postmenopausal African-American women.

AB - This study evaluated 3 index-based dietary patterns - Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010 - in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders. We found that higher AHEI-2010 scores, but not HEI-2005 or HEI-2010 scores, were associated with lower risk of ovarian cancer (comparing the highest quartile (4th) vs. lowest (1st), odds ratio (OR) = 0.66, 95% confidence interval (CI): 0.45, 0.98; P for trend = 0.05). When stratified by menopausal status, no noteworthy associations were observed among premenopausal women. However, among postmenopausal women, greater adherence to HEI-2010 (quartile 4 vs. quartile 1, OR = 0.57, 95% CI: 0.36, 0.92; P for trend = 0.03) and AHEI-2010 (quartile 4 vs. quartile 1, OR = 0.49, 95% CI: 0.31, 0.78; P for trend = 0.01) were inversely associated with ovarian cancer. Our findings indicate that adherence to an overall healthy dietary pattern may reduce ovarian cancer risk in African-American women, and particularly among postmenopausal African-American women.

UR - http://www.scopus.com/inward/record.url?scp=85021967053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021967053&partnerID=8YFLogxK

U2 - 10.1093/aje/kwx022

DO - 10.1093/aje/kwx022

M3 - Article

C2 - 28535290

AN - SCOPUS:85021967053

VL - 185

SP - 1281

EP - 1289

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 12

ER -