Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging

Ann Zenobia Moore, Giorgio Caturegli, E. Metter, Sokratis Makrogiannis, Susan M. Resnick, Tamara B. Harris, Luigi Ferrucci

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objectives To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality. Design Cross-sectional study. Setting Baltimore Longitudinal Study of Aging. Participants Seven hundred eighty-six individuals with a mean age of 66.3 (range 26-96) (N = 786). A sensitivity analysis was conducted in a subset of participants matched according to sex, muscle mass, and body size. Measurements Muscle quality was operationalized as the ratio of knee-extension strength (isokinetic dynamometry) to thigh muscle cross-sectional area (computed tomography). Differences in muscle strength, muscle area, and muscle quality ratio with age were evaluated, and the association between the muscle quality ratio and measures reflecting domains of cognitive function, motor control, peripheral nerve function, adiposity, glucose homeostasis, and inflammation were assessed through multivariate regression analyses. Results A linear relationship between age and muscle quality ratio was observed, suggesting a gradual decline in muscle quality over the adult life course. Associations were observed between muscle quality ratio and measures of adiposity, as well as peroneal nerve motor conduction velocity, finger tapping speed, and memory performance (P <.01). The association between muscle quality ratio and nerve conduction velocity was maintained after adjustment for anthropometric measurements (P <.05). Conclusion Muscle quality declines progressively with age over the adult life span and is affected by obesity and neurological factors. Studies are needed to clarify the mechanisms of these associations and their implications for functional outcomes.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalJournal of the American Geriatrics Society
Volume62
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

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Baltimore
Longitudinal Studies
Muscles
Neural Conduction
Adiposity
Peroneal Nerve
Muscle Strength
Body Size
Proxy
Thigh
Peripheral Nerves
Cognition
Fingers

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging. / Moore, Ann Zenobia; Caturegli, Giorgio; Metter, E.; Makrogiannis, Sokratis; Resnick, Susan M.; Harris, Tamara B.; Ferrucci, Luigi.

In: Journal of the American Geriatrics Society, Vol. 62, No. 2, 01.02.2014, p. 230-236.

Research output: Contribution to journalArticle

Moore, Ann Zenobia ; Caturegli, Giorgio ; Metter, E. ; Makrogiannis, Sokratis ; Resnick, Susan M. ; Harris, Tamara B. ; Ferrucci, Luigi. / Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging. In: Journal of the American Geriatrics Society. 2014 ; Vol. 62, No. 2. pp. 230-236.
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