Differences in the applicability of the Easson-Stedman hypothesis to the α1- and α2-adrenergic effects of phenethylamines and imidazolines

Robert R. Ruffolo, Peter J. Rice, Popat N. Patil, Akihiko Hamada, Duane Miller

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The enantiomers of 2-(3,4,α-trihydroxybenzyl)imidazoline and the corresponding desoxy derivative, 2-(3,4-dihydroxybenzyl)imidazoline, were evaluated at α1- and α2-adrenergic receptors to test the applicability of the Easson-Stedman hypothesis to the imidazoline class of α-adrenergic agonists. A series of closely related phenethylamines was included for comparison. The Easson-Stedman hypothesis states that optically active adrenergic agonists possessing an asymmetric hydroxyl-substituted benzylic carbon atom will have the following relative potencies: R(-) > S(+) = desoxy. While the phenethylamines were found to adhere to the Easson-Stedman hypothesis at both α1- and α2-adrenergic receptors, the optically active imidazolines did not. These findings further support our previous observations that the phenethylamines and imidazolines may interact differently with α-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalEuropean Journal of Pharmacology
Volume86
Issue number3-4
DOIs
StatePublished - Jan 21 1983
Externally publishedYes

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Imidazolines
Phenethylamines
Adrenergic Agents
Adrenergic Receptors
Adrenergic Agonists
Hydroxyl Radical
Carbon

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Differences in the applicability of the Easson-Stedman hypothesis to the α1- and α2-adrenergic effects of phenethylamines and imidazolines. / Ruffolo, Robert R.; Rice, Peter J.; Patil, Popat N.; Hamada, Akihiko; Miller, Duane.

In: European Journal of Pharmacology, Vol. 86, No. 3-4, 21.01.1983, p. 471-475.

Research output: Contribution to journalArticle

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