Differences in the association between serum leptin levels and body mass index in black and white women

A report from the southern community cohort study

Sarah S. Cohen, Jay Fowke, Qiuyin Cai, MacIej S. Buchowski, Lisa B. Signorello, Margaret K. Hargreaves, Wei Zheng, William J. Blot, Charles E. Matthews

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: Leptin may be an important link between obesity and many high-burden diseases, including cancer and cardiovascular disease, but leptin levels and correlates in individuals of diverse racial backgrounds have not been well characterized despite racial differences in incidence and mortality patterns for many obesity-related diseases. Methods: In a cross-sectional study of 915 white and 892 black women enrolled in the Southern Community Cohort Study (age 40-79 years, half postmenopausal), serum leptin levels were compared between the race groups and across categories of body mass index (BMI). Potential correlates of leptin were assessed via race-stratified linear regression models. Results: Blacks had higher unadjusted leptin levels than whites (geometric mean 22.4 vs. 19.0 ng/ml; p < 0.0001). Leptin increased with increasing BMI, and racial differences in leptin were most pronounced in women with BMI ≥25. Significant correlates of leptin included BMI, age, alcohol consumption, cigarette smoking, diabetes (both races) and fat consumption (black women only). Leptin remained higher in black women (22.7 vs. 18.8 ng/ml) after adjustment for these factors. Conclusions: Persistent racial differences in leptin concentrations exist after adjustment for BMI and other factors. Leptin assessment may be informative in future studies that investigate racial differences in the development of obesity-related diseases.

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalAnnals of Nutrition and Metabolism
Volume60
Issue number2
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

Leptin
Body Mass Index
Cohort Studies
Serum
Obesity
Linear Models
hydroquinone
Alcohol Drinking
Cardiovascular Diseases
Cross-Sectional Studies
Smoking
Fats
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Differences in the association between serum leptin levels and body mass index in black and white women : A report from the southern community cohort study. / Cohen, Sarah S.; Fowke, Jay; Cai, Qiuyin; Buchowski, MacIej S.; Signorello, Lisa B.; Hargreaves, Margaret K.; Zheng, Wei; Blot, William J.; Matthews, Charles E.

In: Annals of Nutrition and Metabolism, Vol. 60, No. 2, 01.05.2012, p. 90-97.

Research output: Contribution to journalArticle

Cohen, Sarah S. ; Fowke, Jay ; Cai, Qiuyin ; Buchowski, MacIej S. ; Signorello, Lisa B. ; Hargreaves, Margaret K. ; Zheng, Wei ; Blot, William J. ; Matthews, Charles E. / Differences in the association between serum leptin levels and body mass index in black and white women : A report from the southern community cohort study. In: Annals of Nutrition and Metabolism. 2012 ; Vol. 60, No. 2. pp. 90-97.
@article{a4f708d77787422a94ea4220722c5622,
title = "Differences in the association between serum leptin levels and body mass index in black and white women: A report from the southern community cohort study",
abstract = "Background/Aims: Leptin may be an important link between obesity and many high-burden diseases, including cancer and cardiovascular disease, but leptin levels and correlates in individuals of diverse racial backgrounds have not been well characterized despite racial differences in incidence and mortality patterns for many obesity-related diseases. Methods: In a cross-sectional study of 915 white and 892 black women enrolled in the Southern Community Cohort Study (age 40-79 years, half postmenopausal), serum leptin levels were compared between the race groups and across categories of body mass index (BMI). Potential correlates of leptin were assessed via race-stratified linear regression models. Results: Blacks had higher unadjusted leptin levels than whites (geometric mean 22.4 vs. 19.0 ng/ml; p < 0.0001). Leptin increased with increasing BMI, and racial differences in leptin were most pronounced in women with BMI ≥25. Significant correlates of leptin included BMI, age, alcohol consumption, cigarette smoking, diabetes (both races) and fat consumption (black women only). Leptin remained higher in black women (22.7 vs. 18.8 ng/ml) after adjustment for these factors. Conclusions: Persistent racial differences in leptin concentrations exist after adjustment for BMI and other factors. Leptin assessment may be informative in future studies that investigate racial differences in the development of obesity-related diseases.",
author = "Cohen, {Sarah S.} and Jay Fowke and Qiuyin Cai and Buchowski, {MacIej S.} and Signorello, {Lisa B.} and Hargreaves, {Margaret K.} and Wei Zheng and Blot, {William J.} and Matthews, {Charles E.}",
year = "2012",
month = "5",
day = "1",
doi = "10.1159/000336180",
language = "English (US)",
volume = "60",
pages = "90--97",
journal = "Annals of Nutrition and Metabolism",
issn = "0250-6807",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Differences in the association between serum leptin levels and body mass index in black and white women

T2 - A report from the southern community cohort study

AU - Cohen, Sarah S.

AU - Fowke, Jay

AU - Cai, Qiuyin

AU - Buchowski, MacIej S.

AU - Signorello, Lisa B.

AU - Hargreaves, Margaret K.

AU - Zheng, Wei

AU - Blot, William J.

AU - Matthews, Charles E.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background/Aims: Leptin may be an important link between obesity and many high-burden diseases, including cancer and cardiovascular disease, but leptin levels and correlates in individuals of diverse racial backgrounds have not been well characterized despite racial differences in incidence and mortality patterns for many obesity-related diseases. Methods: In a cross-sectional study of 915 white and 892 black women enrolled in the Southern Community Cohort Study (age 40-79 years, half postmenopausal), serum leptin levels were compared between the race groups and across categories of body mass index (BMI). Potential correlates of leptin were assessed via race-stratified linear regression models. Results: Blacks had higher unadjusted leptin levels than whites (geometric mean 22.4 vs. 19.0 ng/ml; p < 0.0001). Leptin increased with increasing BMI, and racial differences in leptin were most pronounced in women with BMI ≥25. Significant correlates of leptin included BMI, age, alcohol consumption, cigarette smoking, diabetes (both races) and fat consumption (black women only). Leptin remained higher in black women (22.7 vs. 18.8 ng/ml) after adjustment for these factors. Conclusions: Persistent racial differences in leptin concentrations exist after adjustment for BMI and other factors. Leptin assessment may be informative in future studies that investigate racial differences in the development of obesity-related diseases.

AB - Background/Aims: Leptin may be an important link between obesity and many high-burden diseases, including cancer and cardiovascular disease, but leptin levels and correlates in individuals of diverse racial backgrounds have not been well characterized despite racial differences in incidence and mortality patterns for many obesity-related diseases. Methods: In a cross-sectional study of 915 white and 892 black women enrolled in the Southern Community Cohort Study (age 40-79 years, half postmenopausal), serum leptin levels were compared between the race groups and across categories of body mass index (BMI). Potential correlates of leptin were assessed via race-stratified linear regression models. Results: Blacks had higher unadjusted leptin levels than whites (geometric mean 22.4 vs. 19.0 ng/ml; p < 0.0001). Leptin increased with increasing BMI, and racial differences in leptin were most pronounced in women with BMI ≥25. Significant correlates of leptin included BMI, age, alcohol consumption, cigarette smoking, diabetes (both races) and fat consumption (black women only). Leptin remained higher in black women (22.7 vs. 18.8 ng/ml) after adjustment for these factors. Conclusions: Persistent racial differences in leptin concentrations exist after adjustment for BMI and other factors. Leptin assessment may be informative in future studies that investigate racial differences in the development of obesity-related diseases.

UR - http://www.scopus.com/inward/record.url?scp=84857132933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857132933&partnerID=8YFLogxK

U2 - 10.1159/000336180

DO - 10.1159/000336180

M3 - Article

VL - 60

SP - 90

EP - 97

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

SN - 0250-6807

IS - 2

ER -