Different coexpressions of arthritis-relevant genes between different body organs and different brain regions in the normal mouse population

Yanhong Cao, Yue Huang, Lishi Wang, JiaQian Zhu, Weikuan Gu

Research output: Contribution to journalArticle

Abstract

Structural changes in different parts of the brain in rheumatoid arthritis (RA) patients have been reported. RA is not regarded as a brain disease. Body organs such as spleen and lung produce RA-relevant genes. We hypothesized that the structural changes in the brain are caused by changes of gene expression in body organs. Changes in different parts of the brain may be affected by altered gene expressions in different body organs. This study explored whether an association between gene expressions of an organ or a body part varies in different brain structures. By examining the association of the 10 most altered genes from a mouse model of spontaneous arthritis in a normal mouse population, we found two groups of gene expression patterns between five brain structures and spleen. The correlation patterns between the prefrontal cortex, nucleus accumbens, and spleen were similar, while the associations between the other three parts of the brain and spleen showed a different pattern. Among overall patterns of the associations between body organs and brain structures, spleen and lung had a similar pattern, and patterns for kidney and liver were similar. Analysis of the five additional known arthritis-relevant genes produced similar results. Analysis of 10 nonrelevant-arthritis genes did not result in a strong association of gene expression or clearly segregated patterns. Our data suggest that abnormal gene expressions in different diseased body organs may influence structural changes in different brain parts.

Original languageEnglish (US)
Pages (from-to)396-402
Number of pages7
JournalGene
Volume515
Issue number2
DOIs
StatePublished - Feb 25 2013

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Arthritis
Brain
Gene Expression
Spleen
Population
Genes
Rheumatoid Arthritis
Lung
Nucleus Accumbens
Brain Diseases
Prefrontal Cortex
Human Body
Kidney
Liver

All Science Journal Classification (ASJC) codes

  • Genetics

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Different coexpressions of arthritis-relevant genes between different body organs and different brain regions in the normal mouse population. / Cao, Yanhong; Huang, Yue; Wang, Lishi; Zhu, JiaQian; Gu, Weikuan.

In: Gene, Vol. 515, No. 2, 25.02.2013, p. 396-402.

Research output: Contribution to journalArticle

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