Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex

Hongwei Dong, Zhenwei Shao, Jeanne M. Nerbonne, Andreas Burkhalter

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Recordings of synaptic responses of pyramidal neurons to feedback (FB) inputs from higher to lower areas of visual cortex show that excitatory synaptic responses are only weakly opposed by disynaptic inhibition. Whether weak inhibition is preserved at high frequencies remains unknown. Whole-cell recordings were performed in pyramidal cells of mouse visual cortex to study the frequency dependence of excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) elicited by feedforward (FF) input from the primary visual cortex (V1) to the higher lateromedial area (LM) and by FB input from the LM to V1. EPSCs showed similar frequency dependencies in FF and FB pathways; the amplitudes decreased during stimulus trains, and the depression was larger at higher frequencies. IPSCs decreased during repetitive stimulation, and the depression increased at higher frequencies. At >20 Hz, the depression of IPSCs in the FB pathway was greater than in the FF pathway. Thus, unlike FF circuits, FB circuits provide balanced excitatory and inhibitory inputs across a wide range of frequencies. This property was shown to be critically important in cortical circuits that modulate the gain of pyramidal cell firing (Chance et al. [2002] Neuron 35:773-782).

Original languageEnglish (US)
Pages (from-to)361-373
Number of pages13
JournalJournal of Comparative Neurology
Volume475
Issue number3
DOIs
StatePublished - Jul 26 2004

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Visual Cortex
Pyramidal Cells
Inhibitory Postsynaptic Potentials
Excitatory Postsynaptic Potentials
Patch-Clamp Techniques
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex. / Dong, Hongwei; Shao, Zhenwei; Nerbonne, Jeanne M.; Burkhalter, Andreas.

In: Journal of Comparative Neurology, Vol. 475, No. 3, 26.07.2004, p. 361-373.

Research output: Contribution to journalArticle

Dong, Hongwei ; Shao, Zhenwei ; Nerbonne, Jeanne M. ; Burkhalter, Andreas. / Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex. In: Journal of Comparative Neurology. 2004 ; Vol. 475, No. 3. pp. 361-373.
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