Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart

Tieqiang Zhao, Wenyuan Zhao, Yuanjian Chen, Li Liu, Robert A. Ahokas, Yao Sun

Research output: Contribution to journalArticle

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Abstract

Aims: The vascular endothelial growth factor (VEGF) family contains four major isoforms and three receptor subtypes. The expressions of each VEGF isoform and receptor subtype in cardiac repair/remodeling after myocardial infarction (MI) remain uncertain and are investigated in the current study. Methods and results: Temporal and spatial expressions of VEGF isoforms and VEGFR subtypes were examined in the infarcted rat heart. Sham-operated rats served as controls. We found that the normal myocardium expressed all VEGF isoforms. Following MI, VEGF-A was only increased in the border zone at day 1 and was significantly decreased in the infarcted heart during the 42 day observation period afterwards. VEGF-B was significantly suppressed in the infarcted heart. VEGF-C and VEGF-D were markedly increased in the infarcted heart in both early and late stages of MI. VEGFR-1 and 2 were significantly decreased in the infarcted heart, while VEGFR-3 was significantly increased, which was primarily expressed in blood vessels and myofibroblasts (myoFb). Conclusions: VEGF isoforms and VEGFR subtypes are differentially expressed in the infarcted heart. Increased VEGF-A in the very early stage of MI suggests the potential role in initiating the cardiac angiogenic response. Suppressed cardiac VEGF-B postMI suggests that it may not be critical to cardiac repair. The presence of enhanced VEGF-C and VEGF-D along with its receptor, VEGFR-3, in various cell types of the infarcted heart suggest that these isoforms may regulate multiple responses during cardiac repair/remodeling.

Original languageEnglish (US)
Pages (from-to)2638-2645
Number of pages8
JournalInternational Journal of Cardiology
Volume167
Issue number6
DOIs
StatePublished - Jan 1 2013

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Vascular Endothelial Growth Factor Receptor
Protein Isoforms
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor B
Vascular Endothelial Growth Factor D
Myocardial Infarction
Vascular Endothelial Growth Factor Receptor-3
Vascular Endothelial Growth Factor C
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Myofibroblasts
Blood Vessels
Myocardium
Observation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart. / Zhao, Tieqiang; Zhao, Wenyuan; Chen, Yuanjian; Liu, Li; Ahokas, Robert A.; Sun, Yao.

In: International Journal of Cardiology, Vol. 167, No. 6, 01.01.2013, p. 2638-2645.

Research output: Contribution to journalArticle

Zhao, Tieqiang ; Zhao, Wenyuan ; Chen, Yuanjian ; Liu, Li ; Ahokas, Robert A. ; Sun, Yao. / Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart. In: International Journal of Cardiology. 2013 ; Vol. 167, No. 6. pp. 2638-2645.
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