Differential inhibition by prostaglandins of the renal actions of pressor stimuli

Andrew J. Lonigro, Norberto A. Terragno, Kafait Malik, John C. McGiff

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In chloralose-anesthetized dogs, either PGE2, PGA2 or acetylcholine (ACh) infused into a renal artery inhibited reversibly in the experimental kidney vasoconstriction-antidiuresis produced by renal nerve stimulation (RNS) or by pressor hormones given intravenously. The renal actions of RNS were reversed by PGE2 and PGA2, whereas, those of norepinephrine were least affected. PGF did not modify the renal actions of pressor stimuli. ACh inhibited the renal effects of RNS and norepinephrine to the same degree. PGE2 (100 ng/min) inhibited the renal actions of adrenergic stimuli and angiotensin II to the same degree as PGA2, at a dose one-fifth that of PGA2, and at concentrations (ca 0.5 ng/ml blood) comparable to those of a substance, having the properties of PGE2, reported in renal venous effluent during escape from the renal vasoconstrictor-antidiuretic actions of pressor hormones.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalProstaglandins
Volume3
Issue number5
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

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Dinoprostone
Prostaglandins
Kidney
Acetylcholine
Norepinephrine
Hormones
Chloralose
Dinoprost
Vasoconstrictor Agents
Angiotensin II
Adrenergic Agents
Effluents
Blood
prostaglandin A2
Renal Artery
Vasoconstriction
Dogs

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

Differential inhibition by prostaglandins of the renal actions of pressor stimuli. / Lonigro, Andrew J.; Terragno, Norberto A.; Malik, Kafait; McGiff, John C.

In: Prostaglandins, Vol. 3, No. 5, 01.01.1973, p. 595-606.

Research output: Contribution to journalArticle

Lonigro, Andrew J. ; Terragno, Norberto A. ; Malik, Kafait ; McGiff, John C. / Differential inhibition by prostaglandins of the renal actions of pressor stimuli. In: Prostaglandins. 1973 ; Vol. 3, No. 5. pp. 595-606.
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