Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury

R. M. Saroyan, M. P. Roberts, J. T. Light, I. L. Chen, M. Y. Vaccarella, D. J. Bang, Peter Kvamme, S. Singh, S. V. Scalia, M. D. Kerstein, P. J. Kadowitz, D. B. McNamara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The recovery of prostacyclin (prostaglandin I2, PGI2) synthesis and endothelium-derived relaxing factor (EDRF) activity, as demonstrated by acetylcholine (ACh)-induced relaxation, by rabbit aorta was examined up to 8 wk after balloon catheter-induced injury. Following injury, basal 6-keto- PGF(1α) formation was decreased acutely; however, after 3 wk it was not different from control. Arachidonic acid-stimulated 6-keto-PGF(1α) formation was decreased, returning to control levels at 3 and 8 wk for thoracic and abdominal aorta, respectively. ACh-induced relaxation did not return to control levels over the 8-wk study. Initiation of reendothelialization with a layer of hyperplastic endothelial cells overlying subendothelial fibrosis and intimal hyperplasia were present at 2-3 wk. Intimal hyperplasia appeared 2 wk after injury and progressed throughout the period of the study. These data indicate that following balloon catheter-induced injury the formation of both PGI2 and EDRF is reduced and that recovery follows a differential time course. In addition, the recovery of PGI2 formation did not coincide with the attenuation of intimal hyperplasia, whereas the relationship between EDRF formation and intimal hyperplasia is uncertain.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume262
Issue number5 31-5
StatePublished - Jan 1 1992
Externally publishedYes

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Tunica Intima
Endothelium-Dependent Relaxing Factors
Vascular System Injuries
Epoprostenol
Hyperplasia
Wounds and Injuries
Prostaglandins F
Acetylcholine
Catheters
Abdominal Aorta
Thoracic Aorta
Arachidonic Acid
Aorta
Fibrosis
Endothelial Cells
Rabbits

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Saroyan, R. M., Roberts, M. P., Light, J. T., Chen, I. L., Vaccarella, M. Y., Bang, D. J., ... McNamara, D. B. (1992). Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury. American Journal of Physiology - Heart and Circulatory Physiology, 262(5 31-5).

Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury. / Saroyan, R. M.; Roberts, M. P.; Light, J. T.; Chen, I. L.; Vaccarella, M. Y.; Bang, D. J.; Kvamme, Peter; Singh, S.; Scalia, S. V.; Kerstein, M. D.; Kadowitz, P. J.; McNamara, D. B.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 262, No. 5 31-5, 01.01.1992.

Research output: Contribution to journalArticle

Saroyan, RM, Roberts, MP, Light, JT, Chen, IL, Vaccarella, MY, Bang, DJ, Kvamme, P, Singh, S, Scalia, SV, Kerstein, MD, Kadowitz, PJ & McNamara, DB 1992, 'Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury', American Journal of Physiology - Heart and Circulatory Physiology, vol. 262, no. 5 31-5.
Saroyan, R. M. ; Roberts, M. P. ; Light, J. T. ; Chen, I. L. ; Vaccarella, M. Y. ; Bang, D. J. ; Kvamme, Peter ; Singh, S. ; Scalia, S. V. ; Kerstein, M. D. ; Kadowitz, P. J. ; McNamara, D. B. / Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury. In: American Journal of Physiology - Heart and Circulatory Physiology. 1992 ; Vol. 262, No. 5 31-5.
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