Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla

Ralf G. Rahwan, Patrick J. O'Neil, Duane Miller

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Acetaldehyde, the primary metabolite of ethanol, condenses with endogenous amines to form tetrahydroisoquinoline derivatives which have been implicated in the behavioral and autonomic effects of alcohol. Because of difficulties encountered in the in vitro synthesis of the tetrahydroisoquinolines derived from the condensation of acetaldehyde with epinephrine or norepinephrine, their "in tissue" biosynthesis in the isolated perfused bovine adrenal medulla was undertaken, and their mechanism of release investigated. When calcium was present in the perfusion medium, acetaldehyde evoked release of catecholamines as well as synthesis and release of their tetrahydroisoquinoline condensation products. In the absence of calcium in the perfusion medium, acetaldehyde induced the syntheis of tetrahydroisoquinolines but evoked the release of catecholamines only. The results indicate that the release of catecholamines and their tetrahydroisoquinoline derivatives can be uncoupled, and their differential secretion from the adrenal medulla achieved by altering the ionic composition of the extracellular fluid.

Original languageEnglish (US)
Pages (from-to)1927-1938
Number of pages12
JournalLife Sciences
Volume14
Issue number10
DOIs
StatePublished - May 16 1974
Externally publishedYes

Fingerprint

Tetrahydroisoquinolines
Adrenal Medulla
Acetaldehyde
Catecholamines
Condensation
Perfusion
Autonomic Agents
Calcium
Derivatives
Biosynthesis
Extracellular Fluid
Metabolites
Epinephrine
Amines
Norepinephrine
Ethanol
Alcohols
Tissue
Fluids
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla. / Rahwan, Ralf G.; O'Neil, Patrick J.; Miller, Duane.

In: Life Sciences, Vol. 14, No. 10, 16.05.1974, p. 1927-1938.

Research output: Contribution to journalArticle

Rahwan, Ralf G. ; O'Neil, Patrick J. ; Miller, Duane. / Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla. In: Life Sciences. 1974 ; Vol. 14, No. 10. pp. 1927-1938.
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