Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla

R. G. Rahwan, P. J. O'Neill, Duane Miller

Research output: Contribution to journalArticle

Abstract

Acetaldehyde, the primary metabolite of ethanol, condenses with endogenous amines to form tetrahydroisoquinoline (TIQ) derivatives which have been implicated in the behavioral and autonomic effects of alcohol. Because of difficulties encountered in the in vitro synthesis of the TIQs derived from the condensation of acetaldehyde with epinephrine or norepinephrine, their 'in tissue' synthesis in the isolated perfused bovine adrenal medulla was undertaken, and their mechanism of release investigated. When calcium was present in the perfusion medium, acetaldehyde evoked the release of catecholamines as well as the synthesis and release of their TIQ condensation products. In the absence of calcium in the perfusion medium, acetaldehyde induced the synthesis of TIQs but evoked the release of the catecholamines only. The results indicate that the release of catecholamines and their TIQ derivatives can be uncoupled, and their differential secretion from the adrenal medulla achieved by altering the ionic composition of the extracellular fluid.

Original languageEnglish (US)
Number of pages1
JournalFederation Proceedings
Volume33
Issue number3 I
StatePublished - Jan 1 1974
Externally publishedYes

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Tetrahydroisoquinolines
Adrenal Medulla
Acetaldehyde
Catecholamines
Perfusion
Autonomic Agents
Calcium
Extracellular Fluid
Epinephrine
Amines
Norepinephrine
Ethanol
Alcohols

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla. / Rahwan, R. G.; O'Neill, P. J.; Miller, Duane.

In: Federation Proceedings, Vol. 33, No. 3 I, 01.01.1974.

Research output: Contribution to journalArticle

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