Diffuse large-cell lymphoma of B-cell origin and deficient T-cell function in a patient with rheumatoid arthritis

Alva Weir, H. G. Herrod, E. P. Lester, J. Holbert

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6 Citations (Scopus)

Abstract

An increased incidence of non-Hodgkin's lymphoma has been described in patients with rheumatoid arthritis. Mechanisms related to abnormal immune regulation have been postulated, but no patients with rheumatoid arthritis and lymphoma have been previously well characterized immunologically. We describe here a patient with long-standing rheumatoid arthritis in whom a B-cell diffuse large-cell lymphoma developed. He was found to have a severe T-cell immunodeficiency and evidence of persistent Epstein-Barr virus infection. Epstein-Barr nuclear antigen was not found to be present within lymphoma cells. The combination of defective T-cell function and persistent Epstein-Barr virus infection may have predisposed this patient with rheumatoid arthritis to the development of a malignant clone of B lymphocytes.

Original languageEnglish (US)
Pages (from-to)1688-1690
Number of pages3
JournalArchives of Internal Medicine
Volume149
Issue number7
StatePublished - Jan 1 1989

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Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Rheumatoid Arthritis
T-Lymphocytes
Epstein-Barr Virus Infections
Lymphoma
B-Lymphocytes
Nuclear Antigens
Non-Hodgkin's Lymphoma
Clone Cells
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Diffuse large-cell lymphoma of B-cell origin and deficient T-cell function in a patient with rheumatoid arthritis. / Weir, Alva; Herrod, H. G.; Lester, E. P.; Holbert, J.

In: Archives of Internal Medicine, Vol. 149, No. 7, 01.01.1989, p. 1688-1690.

Research output: Contribution to journalArticle

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