Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan

Khader M. Hasan, Arash Kamali, Larry A. Kramer, Andrew Papanicolaou, Jack M. Fletcher, Linda Ewing-Cobbs

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The midsagittal corpus callosum (CC) cross-sectional area subdivisions have been used as early and sensitive markers of human brain white matter connectivity, development, natural aging and disease. Despite the simplicity and conspicuity of the appearance of the CC on anatomical magnetic resonance imaging (MRI), the published quantitative MRI literature on its regional sex and age trajectories are contradictory. The availability of noninvasive quantitative methods to assess the CC regions across the human lifespan would help clarify its contribution to behavior and cognition. In this report, we extended the utility of a recently described semi-automated diffusion tensor imaging (DTI) tissue segmentation method to utilize the high orientation contrast of the CC on DTI. Using optimized DTI methods on a cohort of 121 right-handed children and adults aged 6-68 years, we examined the CC areas and corresponding DTI metrics of the different functionally specialized sectors of the CC. Both the area and fractional anisotropy metrics followed inverted U-shaped curves, while the mean and radial diffusivities followed U-curves reflecting white matter progressive and regressive myelination dynamics that continue into young adulthood.

Original languageEnglish (US)
Pages (from-to)52-67
Number of pages16
JournalBrain Research
Volume1227
DOIs
StatePublished - Aug 28 2008

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Corpus Callosum
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Anisotropy
Cognition
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Hasan, K. M., Kamali, A., Kramer, L. A., Papanicolaou, A., Fletcher, J. M., & Ewing-Cobbs, L. (2008). Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan. Brain Research, 1227, 52-67. https://doi.org/10.1016/j.brainres.2008.06.030

Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan. / Hasan, Khader M.; Kamali, Arash; Kramer, Larry A.; Papanicolaou, Andrew; Fletcher, Jack M.; Ewing-Cobbs, Linda.

In: Brain Research, Vol. 1227, 28.08.2008, p. 52-67.

Research output: Contribution to journalArticle

Hasan, KM, Kamali, A, Kramer, LA, Papanicolaou, A, Fletcher, JM & Ewing-Cobbs, L 2008, 'Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan', Brain Research, vol. 1227, pp. 52-67. https://doi.org/10.1016/j.brainres.2008.06.030
Hasan, Khader M. ; Kamali, Arash ; Kramer, Larry A. ; Papanicolaou, Andrew ; Fletcher, Jack M. ; Ewing-Cobbs, Linda. / Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan. In: Brain Research. 2008 ; Vol. 1227. pp. 52-67.
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