Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan

Khader M. Hasan, Arash Kamali, Amal Iftikhar, Larry A. Kramer, Andrew Papanicolaou, Jack M. Fletcher, Linda Ewing-Cobbs

Research output: Contribution to journalArticle

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Abstract

Several anatomical attributes of the human corpus callosum (CC) including the midsagittal cross-sectional area, thickness, and volume, have been used to assess CC integrity. We extended our previous lifespan quantitative diffusion tensor imaging (DTI) study of the regional CC midsagittal areas to include the CC volumes obtained from DTI fiber tracking. In addition to the entire CC tracked subvolumes we normalized volume with respect to each subject's intracranial volume (ICV) and the corresponding DTI metrics of the different specialized fiber pathways of the CC on a cohort of 99 right-handed children and adults aged 7-59 years. Results indicated that the CC absolute volume, the normalized volume fraction, and the fractional anisotropy followed inverted U-shaped curves, while the radial diffusivities followed a U-shaped curve reflecting white matter progressive and regressive myelination dynamics that continue into young adulthood. Our study provides for the first time normative baseline macro- and microstructural age trajectories of the human CC subvolumes across the lifespan that can be helpful for normative behavioral and clinical studies.

Original languageEnglish (US)
Pages (from-to)91-100
Number of pages10
JournalBrain Research
Volume1249
DOIs
StatePublished - Jan 16 2009

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Diffusion Tensor Imaging
Corpus Callosum
Anisotropy

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Hasan, K. M., Kamali, A., Iftikhar, A., Kramer, L. A., Papanicolaou, A., Fletcher, J. M., & Ewing-Cobbs, L. (2009). Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan. Brain Research, 1249, 91-100. https://doi.org/10.1016/j.brainres.2008.10.026

Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan. / Hasan, Khader M.; Kamali, Arash; Iftikhar, Amal; Kramer, Larry A.; Papanicolaou, Andrew; Fletcher, Jack M.; Ewing-Cobbs, Linda.

In: Brain Research, Vol. 1249, 16.01.2009, p. 91-100.

Research output: Contribution to journalArticle

Hasan, KM, Kamali, A, Iftikhar, A, Kramer, LA, Papanicolaou, A, Fletcher, JM & Ewing-Cobbs, L 2009, 'Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan', Brain Research, vol. 1249, pp. 91-100. https://doi.org/10.1016/j.brainres.2008.10.026
Hasan, Khader M. ; Kamali, Arash ; Iftikhar, Amal ; Kramer, Larry A. ; Papanicolaou, Andrew ; Fletcher, Jack M. ; Ewing-Cobbs, Linda. / Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan. In: Brain Research. 2009 ; Vol. 1249. pp. 91-100.
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