Dilated Cardiomyopathy and Cardioskeletal Involvement

I. Wilmot, John Jefferies, T. D. Ryan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dilated cardiomyopathy encompasses a large heterogeneous group of genetically triggered and acquired etiologies. Cardioskeletal involvement in this population is increasingly identified. Recognition of multifactorial causes such as genetics, proteomics, and inflammation offer a more overarching and unifying explanation for cardioskeletal disease. The neuromuscular patient with Duchene muscular dystrophy provides a vivid example of cardioskeletal disease. In such patients the heritable defect in dystrophin leads to abnormal protein formation, inflammation in both cardiac and skeletal myocytes, and ultimately cardioskeletal disease. Similarly, acquired autoimmune inflammatory processes such as dermatomyositis are associated with inflammation and injury of myocytes and can result in cardioskeletal disease. In this chapter we discuss both heritable and acquired etiologies of dilated cardiomyopathy and explain some of the links to cardioskeletal disease. We discuss the evaluation and diagnosis of dilated cardiomyopathy and the subsequent management. Finally, we explore future directions that may further clarify the relationship between dilated cardiomyopathy and cardioskeletal disease.

Original languageEnglish (US)
Title of host publicationCardioskeletal Myopathies in Children and Young Adults
PublisherElsevier Inc.
Pages85-111
Number of pages27
ISBN (Print)9780128000403
DOIs
StatePublished - Jan 1 2017

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Dilated Cardiomyopathy
Inflammation
Dystrophin
Dermatomyositis
Muscular Dystrophies
Skeletal Muscle Fibers
Cardiac Myocytes
Proteomics
Muscle Cells
Wounds and Injuries
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Wilmot, I., Jefferies, J., & Ryan, T. D. (2017). Dilated Cardiomyopathy and Cardioskeletal Involvement. In Cardioskeletal Myopathies in Children and Young Adults (pp. 85-111). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800040-3.00005-4

Dilated Cardiomyopathy and Cardioskeletal Involvement. / Wilmot, I.; Jefferies, John; Ryan, T. D.

Cardioskeletal Myopathies in Children and Young Adults. Elsevier Inc., 2017. p. 85-111.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wilmot, I, Jefferies, J & Ryan, TD 2017, Dilated Cardiomyopathy and Cardioskeletal Involvement. in Cardioskeletal Myopathies in Children and Young Adults. Elsevier Inc., pp. 85-111. https://doi.org/10.1016/B978-0-12-800040-3.00005-4
Wilmot I, Jefferies J, Ryan TD. Dilated Cardiomyopathy and Cardioskeletal Involvement. In Cardioskeletal Myopathies in Children and Young Adults. Elsevier Inc. 2017. p. 85-111 https://doi.org/10.1016/B978-0-12-800040-3.00005-4
Wilmot, I. ; Jefferies, John ; Ryan, T. D. / Dilated Cardiomyopathy and Cardioskeletal Involvement. Cardioskeletal Myopathies in Children and Young Adults. Elsevier Inc., 2017. pp. 85-111
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