Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes

Xianmin Xu, Satoru Kobayashi, Kai Chen, Derek Timm, Paul Volden, Yuan Huang, James Gulick, Zhenyu Yue, Jeffrey Robbins, Paul N. Epstein, Qiangrong Liang

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Background: Autophagy activity is reduced in type 1 diabetic heart, but the functional role remains unclear. Results: Further reduction in autophagy protects against diabetic heart injury, whereas restoration of autophagy exacerbates cardiac damage. Conclusion: The diminished autophagy limits cardiac dysfunction in type 1 diabetes. Significance: Understanding the functional role of autophagy will facilitate drug design to fight diabetic heart disease.

Original languageEnglish (US)
Pages (from-to)18077-18092
Number of pages16
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

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Autophagy
Medical problems
Type 1 Diabetes Mellitus
Wounds and Injuries
Restoration
Heart Injuries
Drug Design
Heart Diseases
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes. / Xu, Xianmin; Kobayashi, Satoru; Chen, Kai; Timm, Derek; Volden, Paul; Huang, Yuan; Gulick, James; Yue, Zhenyu; Robbins, Jeffrey; Epstein, Paul N.; Liang, Qiangrong.

In: Journal of Biological Chemistry, Vol. 288, No. 25, 21.06.2013, p. 18077-18092.

Research output: Contribution to journalArticle

Xu, X, Kobayashi, S, Chen, K, Timm, D, Volden, P, Huang, Y, Gulick, J, Yue, Z, Robbins, J, Epstein, PN & Liang, Q 2013, 'Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes', Journal of Biological Chemistry, vol. 288, no. 25, pp. 18077-18092. https://doi.org/10.1074/jbc.M113.474650
Xu, Xianmin ; Kobayashi, Satoru ; Chen, Kai ; Timm, Derek ; Volden, Paul ; Huang, Yuan ; Gulick, James ; Yue, Zhenyu ; Robbins, Jeffrey ; Epstein, Paul N. ; Liang, Qiangrong. / Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 25. pp. 18077-18092.
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