Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin

B. Keith English, Erik M. Maryniw, Ajay Talati, Elizabeth A. Meals

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nitric oxide synthase protein.

Original languageEnglish (US)
Pages (from-to)2225-2227
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number6
DOIs
StatePublished - Jun 1 2006

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Daptomycin
Oxacillin
Vancomycin
Staphylococcus aureus
Macrophages
Nitric Oxide Synthase Type II
Tumor Necrosis Factor-alpha
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin. / English, B. Keith; Maryniw, Erik M.; Talati, Ajay; Meals, Elizabeth A.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 6, 01.06.2006, p. 2225-2227.

Research output: Contribution to journalArticle

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