Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans

S. Sendhil Velan, Nicholas Said, Christopher Durst, Stephanie Frisbee, Jefferson Frisbee, Raymond R. Raylman, M. Albert Thomas, Vazhaikkurichi M. Rajendran, Richard G. Spencer, Stephen Alway

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The link between body weight, lipid metabolism, and health risks is poorly understood and difficult to study. Magnetic resonance spectroscopy (MRS) permits noninvasive investigation of lipid metabolism. We extended existing two-dimensional MRS techniques to permit quantification of intra- and extramyocellular lipid (IMCL and EMCL, respectively) compartments and their degree of unsaturation in human subjects and correlated these results with body mass index (BMI). Using muscle creatine for normalization, we observed a statistically significant (P < 0.01) increase in the IMCL-to-creatine ratio with BMI (n = 8 subjects per group): 5.9 ± 1.7 at BMI < 25, 10.9 ± 1.82 at 25 < BMI < 30, and 13.1 ± 0.87 at BMI > 30. Similarly, the degree of IMCL unsaturation decreased significantly (P < 0.01) with BMI: 1.51 ± 0.08 at BMI < 25, 1.30 ± 0.11 at 25 < BMI < 30, and 0.90 ± 0.14 at BMI > 30. We conclude that important aspects of lipid metabolism can be evaluated by two-dimensional MRS and propose that degree of unsaturation measured noninvasively may serve as a biomarker for lipid metabolic defects associated with obesity.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume295
Issue number4
DOIs
StatePublished - Oct 1 2008

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Lipid Metabolism
Skeletal Muscle
Magnetic Resonance Spectroscopy
Fats
Weights and Measures
Lipids
Creatine
Body Mass Index
Obesity
Biomarkers
Body Weight
Muscles
Health
P-30 composite resin

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans. / Velan, S. Sendhil; Said, Nicholas; Durst, Christopher; Frisbee, Stephanie; Frisbee, Jefferson; Raylman, Raymond R.; Thomas, M. Albert; Rajendran, Vazhaikkurichi M.; Spencer, Richard G.; Alway, Stephen.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 295, No. 4, 01.10.2008.

Research output: Contribution to journalArticle

Velan, S. Sendhil ; Said, Nicholas ; Durst, Christopher ; Frisbee, Stephanie ; Frisbee, Jefferson ; Raylman, Raymond R. ; Thomas, M. Albert ; Rajendran, Vazhaikkurichi M. ; Spencer, Richard G. ; Alway, Stephen. / Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2008 ; Vol. 295, No. 4.
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