Distribution of lipids in 8,500 men with coronary artery disease

Hanna Bloomfield Rubins, Sander J. Robins, Dorothea Collins, Ali Iranmanesh, Timothy J. Wilt, Douglas Mann, Michael Mayo-Smith, Fred H. Faas, Marshall Elam, Gale H. Rutan, James W. Anderson, Moti L. Kashyap, Gordon Schectman

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Abstract

In the present study we measured fasting lipid profiles in over 8,500 community-living men with coronary artery disease (CAD) to determine the distribution of lipid abnormalities in this population: 81% were white and 16% black; mean age 62.9 ± 8 years; mean total cholesterol 214 ± 41 mg/dl; low-density lipoprotein (LDL) cholesterol 140 ± 37 mg/dl; high-density lipoprotein (HDL) cholesterol 39 ± 11 mg/dl; and triglycerides 190 ± 142 mg/dl. After adjusting for age, the only significant difference between blacks and whites was a higher HDL cholesterol in blacks (45 vs 38 mg/dl, p < 0.003). With use of cut points established by the National Cholesterol Education Program, 87% or subjects had high LDL cholesterol (≥100 mg/dl), 38% had low HDL cholesterol (<35 mg/dl), and 33% had high triglycerides (>200 mg/dl). We estimated that 42% of men with CAD would be definite candidates for cholesterol-lowering medication according to the National Cholesterol Education Program guidelines and that 41% of those in whom cholesterol-lowering medication would not be definitely indicated had low levels of HDL cholesterol. We conclude that (1) black men with CAD have substantially higher HDL cholesterol than white men, (2) almost 90% of male patients with CAD are candidates for dietary intervention and >40% may need medications to lower LDL cholesterol, and (3) 40% of patients without a definite indication for cholesterol-lowering medications have low levels of HDL cholesterol.

Original languageEnglish (US)
Pages (from-to)1196-1201
Number of pages6
JournalThe American Journal of Cardiology
Volume75
Issue number17
DOIs
StatePublished - Jun 15 1995

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HDL Cholesterol
Coronary Artery Disease
Cholesterol
Lipids
LDL Cholesterol
Fasting
Triglycerides
Guidelines
Education
Population
hydroquinone

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Rubins, H. B., Robins, S. J., Collins, D., Iranmanesh, A., Wilt, T. J., Mann, D., ... Schectman, G. (1995). Distribution of lipids in 8,500 men with coronary artery disease. The American Journal of Cardiology, 75(17), 1196-1201. https://doi.org/10.1016/S0002-9149(99)80761-9

Distribution of lipids in 8,500 men with coronary artery disease. / Rubins, Hanna Bloomfield; Robins, Sander J.; Collins, Dorothea; Iranmanesh, Ali; Wilt, Timothy J.; Mann, Douglas; Mayo-Smith, Michael; Faas, Fred H.; Elam, Marshall; Rutan, Gale H.; Anderson, James W.; Kashyap, Moti L.; Schectman, Gordon.

In: The American Journal of Cardiology, Vol. 75, No. 17, 15.06.1995, p. 1196-1201.

Research output: Contribution to journalArticle

Rubins, HB, Robins, SJ, Collins, D, Iranmanesh, A, Wilt, TJ, Mann, D, Mayo-Smith, M, Faas, FH, Elam, M, Rutan, GH, Anderson, JW, Kashyap, ML & Schectman, G 1995, 'Distribution of lipids in 8,500 men with coronary artery disease', The American Journal of Cardiology, vol. 75, no. 17, pp. 1196-1201. https://doi.org/10.1016/S0002-9149(99)80761-9
Rubins HB, Robins SJ, Collins D, Iranmanesh A, Wilt TJ, Mann D et al. Distribution of lipids in 8,500 men with coronary artery disease. The American Journal of Cardiology. 1995 Jun 15;75(17):1196-1201. https://doi.org/10.1016/S0002-9149(99)80761-9
Rubins, Hanna Bloomfield ; Robins, Sander J. ; Collins, Dorothea ; Iranmanesh, Ali ; Wilt, Timothy J. ; Mann, Douglas ; Mayo-Smith, Michael ; Faas, Fred H. ; Elam, Marshall ; Rutan, Gale H. ; Anderson, James W. ; Kashyap, Moti L. ; Schectman, Gordon. / Distribution of lipids in 8,500 men with coronary artery disease. In: The American Journal of Cardiology. 1995 ; Vol. 75, No. 17. pp. 1196-1201.
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