Distribution of transforming growth factor-β isoforms in human immunodeficiency virus-1 encephalitis

Mahlon Johnson, L. I. Gold

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The transforming growth factor-β family of polypeptides includes three related isoforms with pervasive effects on immune system function. In this study, the authors evaluated human brains with human immunodeficiency virus (HIV)-1 encephalitis for transforming growth factor β (TGFβ)1, TGFβ2, and TGFβ3 immunoreactivity using isoform-specific polyclonal antibodies and avidin-biotin immunohistochemistry. Normal brains and those with progressive multifocal leukoencephalopathy, toxoplasma encephalitis, and cryptococcal meningitis were used as controls. In normal controls, TGFβ1, TGFβ2, and TGFβ3 immunoreactivity were confined to arachnoid cells and blood vessels. In 9 of 10 cases of HIV-1 encephalitis, all three isoforms were also detected in arachnoid cells. In addition, variable, predominantly TGFβ2 and TGFβ3 immunoreactivity were also detected in reactive astrocytes and mononuclear cells of white matter lesions. Extensive TGFβ3 immunoreactivity was also detected in multinucleated giant cells in one case. In a case of cryptocoeval meningitis, all three isoforms were detected in arachnoid cells and macrophages. Lesions of progressive multifocal leukoencephalopathy and toxoplasma encephalitis also exhibited TGFβ1, TGFβ2, and TGFβ3 immunostaining in reactive astrocytes. These findings suggest that TGFβ isoforms are present in HIV-1 encephalitis and may participate in the pathogenesis of this and other inflammatory central nervous system (CNS) lesions associated with acquired immunodeficiency syndrome (AIDS).

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalHuman pathology
Volume27
Issue number7
DOIs
StatePublished - Jan 1 1996

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Transforming Growth Factors
Encephalitis
HIV-1
Protein Isoforms
Arachnoid
Progressive Multifocal Leukoencephalopathy
Toxoplasma
Astrocytes
Cryptococcal Meningitis
Avidin
Brain
Giant Cells
Biotin
Meningitis
Blood Vessels
Immune System
Acquired Immunodeficiency Syndrome
Central Nervous System
Immunohistochemistry
Macrophages

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Distribution of transforming growth factor-β isoforms in human immunodeficiency virus-1 encephalitis. / Johnson, Mahlon; Gold, L. I.

In: Human pathology, Vol. 27, No. 7, 01.01.1996, p. 643-649.

Research output: Contribution to journalArticle

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