Distribution of Viral Glycoprotein gp 69/71 on Cell Surfaces of Producer and Nonproducer Cells

Stephen Kennel, Joseph D. Feldman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The distribution of the viral glycoprotein, gp 69/71, was studied on the cell surfaces of virus-producing and nonproducing cells, gp 69/71 was distributed evenly on cell membranes and on viral membranes of cells producing murine leukemia virus. gp 69/71 was distributed uniformly on cell membranes of thymocytes from NZB and strain 129 mice but was not detected on cell membranes of BALB/c thymocytes. Viral particles were associated with NZB and BALB/c thymocytes but were not in or on 129 thymocytes. We conclude that the presence of gp 69/71 on thymocyte membranes is not related to virus production. In the strains showing gp 69/71 on their thymocyte surfaces (NZB and 129), a large percentage of the thymocytes are positively labeled, all more or less equally. Immunochemical analysis of cell surface proteins labeled with 125l corroborated the ultrastructural observations. Thus, gp 69/71 can be expressed on the surface of thymocytes independently of virus particle production.

Original languageEnglish (US)
Pages (from-to)200-208
Number of pages9
JournalCancer Research
Volume36
Issue number1
StatePublished - Jan 1 1976

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Thymocytes
Glycoproteins
Cell Membrane
Virion
129 Strain Mouse
Viruses
Murine Leukemia Viruses
Membrane Proteins
Membranes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Distribution of Viral Glycoprotein gp 69/71 on Cell Surfaces of Producer and Nonproducer Cells. / Kennel, Stephen; Feldman, Joseph D.

In: Cancer Research, Vol. 36, No. 1, 01.01.1976, p. 200-208.

Research output: Contribution to journalArticle

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