DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia

A report from the Childhood Cancer Survivor Study

Philip J. Lupo, Austin L. Brown, Vidal M. Arroyo, Kala Y. Kamdar, John W. Belmont, Michael E. Scheurer, Wendy M. Leisenring, M. Monica Gramatges, M. Fatih Okcu, Yutaka Yasui, Kevin C. Oeffinger, Leslie L. Robison, Gregory Armstrong, Smita Bhatia

Research output: Contribution to journalArticle

Abstract

Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and obese survivors at adiposity-associated CpG sites previously-reported by epigenome-wide association studies (EWAS) of body mass index (BMI) in the general population. We selected 96 ALL survivors from the Childhood Cancer Survivor Study: 48 obese and 48 normal weight. The Illumina HumanMethylation450 BeadChip was used to compare DNA methylation at 211 loci identified in EWAS of BMI in the general population. Thirty-nine loci were associated (false discovery rate <0.05) with obesity among survivors who only received chemotherapy (n = 49). No loci were significantly associated with obesity among CRT-exposed survivors (n = 47). Our results suggest that previously identified BMI-DNA methylation loci are associated with obesity in ALL survivors who were spared CRT, while no loci were significantly associated with obesity in survivors who received CRT.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalGenes Chromosomes and Cancer
Volume58
Issue number1
DOIs
StatePublished - Jan 1 2019

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DNA Methylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Obesity
Pediatrics
Body Mass Index
Neoplasms
Weights and Measures
Adiposity
Population
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

Cite this

Lupo, P. J., Brown, A. L., Arroyo, V. M., Kamdar, K. Y., Belmont, J. W., Scheurer, M. E., ... Bhatia, S. (2019). DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Genes Chromosomes and Cancer, 58(1), 52-59. https://doi.org/10.1002/gcc.22701

DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia : A report from the Childhood Cancer Survivor Study. / Lupo, Philip J.; Brown, Austin L.; Arroyo, Vidal M.; Kamdar, Kala Y.; Belmont, John W.; Scheurer, Michael E.; Leisenring, Wendy M.; Monica Gramatges, M.; Fatih Okcu, M.; Yasui, Yutaka; Oeffinger, Kevin C.; Robison, Leslie L.; Armstrong, Gregory; Bhatia, Smita.

In: Genes Chromosomes and Cancer, Vol. 58, No. 1, 01.01.2019, p. 52-59.

Research output: Contribution to journalArticle

Lupo, PJ, Brown, AL, Arroyo, VM, Kamdar, KY, Belmont, JW, Scheurer, ME, Leisenring, WM, Monica Gramatges, M, Fatih Okcu, M, Yasui, Y, Oeffinger, KC, Robison, LL, Armstrong, G & Bhatia, S 2019, 'DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study', Genes Chromosomes and Cancer, vol. 58, no. 1, pp. 52-59. https://doi.org/10.1002/gcc.22701
Lupo, Philip J. ; Brown, Austin L. ; Arroyo, Vidal M. ; Kamdar, Kala Y. ; Belmont, John W. ; Scheurer, Michael E. ; Leisenring, Wendy M. ; Monica Gramatges, M. ; Fatih Okcu, M. ; Yasui, Yutaka ; Oeffinger, Kevin C. ; Robison, Leslie L. ; Armstrong, Gregory ; Bhatia, Smita. / DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia : A report from the Childhood Cancer Survivor Study. In: Genes Chromosomes and Cancer. 2019 ; Vol. 58, No. 1. pp. 52-59.
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