Does incorporation of aids and devices make a difference in the score of the health assessment questionnaire-disability index? Analysis from a scleroderma clinical trial

Dinesh Khanna, Philip J. Clements, Arnold Postlethwaite, Daniel E. Furst

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective. The Health Assessment Questionnaire-Disability Index (HAQ-DI) is a commonly used musculoskeletal-targeted measure in systemic sclerosis (SSc). We assessed if HAQ-DI scores are different when calculated with and without aids/devices, and if apparent responsiveness changes when scored in these 2 ways. Methods. We used data from a placebo-controlled clinical trial in diffuse SSc. Baseline HAQ-DI total score was calculated with and without aids/devices and compared using Student's t-test. We also classified the HAQ-DI scores into no-to-mild disability (0.00-1.00), moderate disability (1.01-2.00), and severe disability (2.01-3.00). Responsiveness to change was evaluated using the effect size (ES). Results. The mean (SD) baseline HAQ-DI score was 1.33 (0.68) with aids/devices compared to HAQ-DI score 1.16 (0.70) without aids/devices (p = 0.03). When the baseline HAQ-DI score was categorized into no-to-mild, moderate, and severe disability, the proportion of patients in the no-to-mild disability (29% with aids/devices vs 44% without aids/devices) and moderate disability (59% with aids/devices vs 45% without aids/devices) groups were statistically different (p < 0.001). The ES was similar between the 2 groups (ES = 0.01 and 0.02 with and without aids/devices). Conclusion. This analysis suggests a shift from no-to-mild disability to moderate disability when aids/devices are incorporated in total HAQ-DI score. Future clinical trials in SSc should explicitly state whether HAQ-DI score was calculated using aids/devices.

Original languageEnglish (US)
Pages (from-to)466-468
Number of pages3
JournalJournal of Rheumatology
Volume35
Issue number3
StatePublished - Mar 2008

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Clinical Trials
Equipment and Supplies
Health
Systemic Scleroderma
Surveys and Questionnaires
Diffuse Scleroderma
Controlled Clinical Trials
Placebos
Students

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology

Cite this

Does incorporation of aids and devices make a difference in the score of the health assessment questionnaire-disability index? Analysis from a scleroderma clinical trial. / Khanna, Dinesh; Clements, Philip J.; Postlethwaite, Arnold; Furst, Daniel E.

In: Journal of Rheumatology, Vol. 35, No. 3, 03.2008, p. 466-468.

Research output: Contribution to journalArticle

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abstract = "Objective. The Health Assessment Questionnaire-Disability Index (HAQ-DI) is a commonly used musculoskeletal-targeted measure in systemic sclerosis (SSc). We assessed if HAQ-DI scores are different when calculated with and without aids/devices, and if apparent responsiveness changes when scored in these 2 ways. Methods. We used data from a placebo-controlled clinical trial in diffuse SSc. Baseline HAQ-DI total score was calculated with and without aids/devices and compared using Student's t-test. We also classified the HAQ-DI scores into no-to-mild disability (0.00-1.00), moderate disability (1.01-2.00), and severe disability (2.01-3.00). Responsiveness to change was evaluated using the effect size (ES). Results. The mean (SD) baseline HAQ-DI score was 1.33 (0.68) with aids/devices compared to HAQ-DI score 1.16 (0.70) without aids/devices (p = 0.03). When the baseline HAQ-DI score was categorized into no-to-mild, moderate, and severe disability, the proportion of patients in the no-to-mild disability (29{\%} with aids/devices vs 44{\%} without aids/devices) and moderate disability (59{\%} with aids/devices vs 45{\%} without aids/devices) groups were statistically different (p < 0.001). The ES was similar between the 2 groups (ES = 0.01 and 0.02 with and without aids/devices). Conclusion. This analysis suggests a shift from no-to-mild disability to moderate disability when aids/devices are incorporated in total HAQ-DI score. Future clinical trials in SSc should explicitly state whether HAQ-DI score was calculated using aids/devices.",
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N2 - Objective. The Health Assessment Questionnaire-Disability Index (HAQ-DI) is a commonly used musculoskeletal-targeted measure in systemic sclerosis (SSc). We assessed if HAQ-DI scores are different when calculated with and without aids/devices, and if apparent responsiveness changes when scored in these 2 ways. Methods. We used data from a placebo-controlled clinical trial in diffuse SSc. Baseline HAQ-DI total score was calculated with and without aids/devices and compared using Student's t-test. We also classified the HAQ-DI scores into no-to-mild disability (0.00-1.00), moderate disability (1.01-2.00), and severe disability (2.01-3.00). Responsiveness to change was evaluated using the effect size (ES). Results. The mean (SD) baseline HAQ-DI score was 1.33 (0.68) with aids/devices compared to HAQ-DI score 1.16 (0.70) without aids/devices (p = 0.03). When the baseline HAQ-DI score was categorized into no-to-mild, moderate, and severe disability, the proportion of patients in the no-to-mild disability (29% with aids/devices vs 44% without aids/devices) and moderate disability (59% with aids/devices vs 45% without aids/devices) groups were statistically different (p < 0.001). The ES was similar between the 2 groups (ES = 0.01 and 0.02 with and without aids/devices). Conclusion. This analysis suggests a shift from no-to-mild disability to moderate disability when aids/devices are incorporated in total HAQ-DI score. Future clinical trials in SSc should explicitly state whether HAQ-DI score was calculated using aids/devices.

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