Does influenza vaccination prevent asthma exacerbations in children?

Piotr Kramarz, Frank DeStefano, Paul M. Gargiullo, Robert T. Chen, Tracy A. Lieu, Robert Davis, John P. Mullooly, Steve B. Black, Henry R. Shinefield, Kari Bohlke, Joel I. Ward, S. Michael Marcy

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Objective: Influenza can exacerbate asthma, particularly in children. The effectiveness of influenza vaccine in preventing influenza-related asthma exacerbations, however, is not known. We evaluated influenza vaccine effectiveness in protecting children against influenza-related asthma exacerbations. Study design: We conducted a population-based retrospective cohort study with medical and vaccination records in 4 large health maintenance organizations in the United States during the 1993-1994, 1994-1995, and 1995-1996 influenza seasons. We studied children with asthma who were 1 through 6 years of age and who were identified by search of computerized databases of medical encounters and pharmacy dispensings. Main outcome measures were exacerbations of asthma evaluated in the emergency department or hospital. Results: Unadjusted rates of asthma exacerbations were higher after influenza vaccination than before vaccination. After adjustment was done for asthma severity by means of a self-control method, however, the incidence rate ratios of asthma exacerbations after vaccination were 0.78 (95% CI: 0.55 to 1.10), 0.59 (0.43 to 0.81), and 0.65 (0.52 to 0.80) compared with the period before vaccination during the 3 influenza seasons. Conclusions: After controlling for asthma severity, we found that influenza vaccination protects against acute asthma exacerbations in children.

Original languageEnglish (US)
Pages (from-to)306-310
Number of pages5
JournalJournal of Pediatrics
Volume138
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Human Influenza
Vaccination
Asthma
Influenza Vaccines
Health Maintenance Organizations
Medical Records
Hospital Emergency Service
Cohort Studies
Retrospective Studies
Outcome Assessment (Health Care)
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Kramarz, P., DeStefano, F., Gargiullo, P. M., Chen, R. T., Lieu, T. A., Davis, R., ... Marcy, S. M. (2001). Does influenza vaccination prevent asthma exacerbations in children? Journal of Pediatrics, 138(3), 306-310. https://doi.org/10.1067/mpd.2001.112168

Does influenza vaccination prevent asthma exacerbations in children? / Kramarz, Piotr; DeStefano, Frank; Gargiullo, Paul M.; Chen, Robert T.; Lieu, Tracy A.; Davis, Robert; Mullooly, John P.; Black, Steve B.; Shinefield, Henry R.; Bohlke, Kari; Ward, Joel I.; Marcy, S. Michael.

In: Journal of Pediatrics, Vol. 138, No. 3, 01.01.2001, p. 306-310.

Research output: Contribution to journalArticle

Kramarz, P, DeStefano, F, Gargiullo, PM, Chen, RT, Lieu, TA, Davis, R, Mullooly, JP, Black, SB, Shinefield, HR, Bohlke, K, Ward, JI & Marcy, SM 2001, 'Does influenza vaccination prevent asthma exacerbations in children?', Journal of Pediatrics, vol. 138, no. 3, pp. 306-310. https://doi.org/10.1067/mpd.2001.112168
Kramarz P, DeStefano F, Gargiullo PM, Chen RT, Lieu TA, Davis R et al. Does influenza vaccination prevent asthma exacerbations in children? Journal of Pediatrics. 2001 Jan 1;138(3):306-310. https://doi.org/10.1067/mpd.2001.112168
Kramarz, Piotr ; DeStefano, Frank ; Gargiullo, Paul M. ; Chen, Robert T. ; Lieu, Tracy A. ; Davis, Robert ; Mullooly, John P. ; Black, Steve B. ; Shinefield, Henry R. ; Bohlke, Kari ; Ward, Joel I. ; Marcy, S. Michael. / Does influenza vaccination prevent asthma exacerbations in children?. In: Journal of Pediatrics. 2001 ; Vol. 138, No. 3. pp. 306-310.
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