Does syndrome X exist in hypertensive elderly persons with impaired glycemic control?

Karen Johnson, M. J. Graney, W. B. Applegate, A. E. Kitabchi, J. W. Runyan, G. H. Rutan

Research output: Contribution to journalArticle

Abstract

A cross-sectional study was performed on 95 participants in the Trial of Nonpharmacologic Interventions in the Elderly (TONE) study who agreed to participate in an ancillary study. A standard OGTT with insulin and C-peptide levels and a fasting lipid profile were obtained. Beta cell function and peripheral insulin resistance were estimated using the method of Sluiter. Results: In this sample of elderly participants with hypertension who were taking an antihypertensive medication, 43 (45.3%) had normal glucose tolerance (NGT), 41 (43.2%) had impaired glucose tolerance (IGT), and 11 (11.6%) had undiagnosed noninsulin dependent diabetes mellitus (NIDDM). Fasting hyperinsulinemia occurred in only one participant, who was in the IGT group. Hypertriglyceridemia and low HDL occurred in 4 persons, none of whom had hyperinsulinemia. Persons in the NIDDM and IGT groups had decreased beta cell function compared to persons in the NGT group, but did not have increased peripheral insulin resistance as estimated from the OGTT data. Conclusions: Our data demonstrated that in this cohort of elderly hypertensive participants with a high prevalence of central obesity, impaired glycemic control was common, but was not associated with fasting hyperinsulinemia or peripheral insulin resistance. Furthermore, we conclude that syndrome X essentially did not occur in these participants and postulate that the primary etiology for their impaired glycemic control is beta cell dysfunction. Further research is needed to elucidate these relationships.

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume47
Issue number2
StatePublished - Jan 1 1999

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Glucose Intolerance
Hyperinsulinism
Vascular Resistance
Insulin Resistance
Fasting
Glucose Tolerance Test
Glucose
Type 2 Diabetes Mellitus
Insulin
Medical problems
Abdominal Obesity
C-Peptide
Hypertriglyceridemia
Antihypertensive Agents
Cross-Sectional Studies
Hypertension
Lipids
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Johnson, K., Graney, M. J., Applegate, W. B., Kitabchi, A. E., Runyan, J. W., & Rutan, G. H. (1999). Does syndrome X exist in hypertensive elderly persons with impaired glycemic control? Journal of Investigative Medicine, 47(2).

Does syndrome X exist in hypertensive elderly persons with impaired glycemic control? / Johnson, Karen; Graney, M. J.; Applegate, W. B.; Kitabchi, A. E.; Runyan, J. W.; Rutan, G. H.

In: Journal of Investigative Medicine, Vol. 47, No. 2, 01.01.1999.

Research output: Contribution to journalArticle

Johnson, K, Graney, MJ, Applegate, WB, Kitabchi, AE, Runyan, JW & Rutan, GH 1999, 'Does syndrome X exist in hypertensive elderly persons with impaired glycemic control?', Journal of Investigative Medicine, vol. 47, no. 2.
Johnson, Karen ; Graney, M. J. ; Applegate, W. B. ; Kitabchi, A. E. ; Runyan, J. W. ; Rutan, G. H. / Does syndrome X exist in hypertensive elderly persons with impaired glycemic control?. In: Journal of Investigative Medicine. 1999 ; Vol. 47, No. 2.
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