Domperidone elevates rat plasma β-endorphin-immunoreactivity when administered peripherally but not intracerebroventricularly

Burt Sharp, B. Kasson, D. Marshak, R. Ross, R. George, J. Sowers, T. Yamada

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Domperidone, a dopamine receptor antagonist which apparently does not penetrate the blood-brain barrier in rats was administered to adult males. Domperidone 500 μg and 100μg, given through intracarotid cannula, significantly elevated plasma β-endorphin- immunoreactivity (β-EP-I) at +15 min. To show that only a peripheral site(s) of action is implicated, domperidone was given to rats by cannulae implanted into both lateral ventricles. Plasma β-EP-I was unaffected by this route of administration. These results suggest that plasma β-EP-I is tonically inhibited by dopamine acting at site(s) outside of the blood-brain barrier.

Original languageEnglish (US)
Pages (from-to)981-985
Number of pages5
JournalLife Sciences
Volume31
Issue number10
DOIs
StatePublished - Sep 6 1982

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Domperidone
Endorphins
Rats
Blood-Brain Barrier
Plasmas
Dopamine Antagonists
Lateral Ventricles
Dopamine
Cannula

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Domperidone elevates rat plasma β-endorphin-immunoreactivity when administered peripherally but not intracerebroventricularly. / Sharp, Burt; Kasson, B.; Marshak, D.; Ross, R.; George, R.; Sowers, J.; Yamada, T.

In: Life Sciences, Vol. 31, No. 10, 06.09.1982, p. 981-985.

Research output: Contribution to journalArticle

Sharp, Burt ; Kasson, B. ; Marshak, D. ; Ross, R. ; George, R. ; Sowers, J. ; Yamada, T. / Domperidone elevates rat plasma β-endorphin-immunoreactivity when administered peripherally but not intracerebroventricularly. In: Life Sciences. 1982 ; Vol. 31, No. 10. pp. 981-985.
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