Dopamine D1 and D2 receptor subtypes functional regulation in cerebral cortex of unilateral rotenone lesioned Parkinson's rat model

Effect of serotonin, dopamine and norepinephrine

Jes Paul, Korah P. Kuruvilla, Jobin Mathew, Peeyush Kumar, C. S. Paulose

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Parkinson's disease is a progressive neurodegenerative disorder characterized by selective degeneration of dopaminergic neurons in substantia nigra pars compacta leading to marked reduction of dopamine levels in the cerebral cortex. The present study analysed the effect of serotonin, dopamine and norepinephrine as treatment on rotenone induced Hemi- Parkinson's disease in rats and its role in the regulation of Dopamine receptor subtypes in the cerebral cortex of the experimental rats. Unilateral stereotaxic single dose infusions of rotenone were administered to the substantia nigra of adult male Wistar rats. Neurotransmitters -serotonin, dopamine and norepinephrine treatments were given to rotenone induced Hemi-Parkinson's rats. Scatchard analysis of Dopamine D1 and D2 receptor showed a significant increase (p < 0.001) in the cerebral cortex of the Parkinson's rats compared to control. These altered parameters were reversed to near control in the serotonin and norepinephrine treated Parkinson's disease rats and no change was observed in Dopamine treated Parkinson's rats. Real-time PCR results confirmed the receptor data. Our results showed serotonin and norepinephrine functionally reversed the Dopamine receptors significantly in rotenone induced Hemi-Parkinson's rat. This has clinical significance in the therapeutic management of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalParkinsonism and Related Disorders
Volume17
Issue number4
DOIs
StatePublished - May 1 2011

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Rotenone
Dopamine D1 Receptors
Dopamine D2 Receptors
Cerebral Cortex
Dopamine
Serotonin
Norepinephrine
Parkinson Disease
Dopamine Receptors
Dopaminergic Neurons
Substantia Nigra
Neurodegenerative Diseases
Neurotransmitter Agents
Wistar Rats
Real-Time Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

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title = "Dopamine D1 and D2 receptor subtypes functional regulation in cerebral cortex of unilateral rotenone lesioned Parkinson's rat model: Effect of serotonin, dopamine and norepinephrine",
abstract = "Parkinson's disease is a progressive neurodegenerative disorder characterized by selective degeneration of dopaminergic neurons in substantia nigra pars compacta leading to marked reduction of dopamine levels in the cerebral cortex. The present study analysed the effect of serotonin, dopamine and norepinephrine as treatment on rotenone induced Hemi- Parkinson's disease in rats and its role in the regulation of Dopamine receptor subtypes in the cerebral cortex of the experimental rats. Unilateral stereotaxic single dose infusions of rotenone were administered to the substantia nigra of adult male Wistar rats. Neurotransmitters -serotonin, dopamine and norepinephrine treatments were given to rotenone induced Hemi-Parkinson's rats. Scatchard analysis of Dopamine D1 and D2 receptor showed a significant increase (p < 0.001) in the cerebral cortex of the Parkinson's rats compared to control. These altered parameters were reversed to near control in the serotonin and norepinephrine treated Parkinson's disease rats and no change was observed in Dopamine treated Parkinson's rats. Real-time PCR results confirmed the receptor data. Our results showed serotonin and norepinephrine functionally reversed the Dopamine receptors significantly in rotenone induced Hemi-Parkinson's rat. This has clinical significance in the therapeutic management of Parkinson's disease.",
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AB - Parkinson's disease is a progressive neurodegenerative disorder characterized by selective degeneration of dopaminergic neurons in substantia nigra pars compacta leading to marked reduction of dopamine levels in the cerebral cortex. The present study analysed the effect of serotonin, dopamine and norepinephrine as treatment on rotenone induced Hemi- Parkinson's disease in rats and its role in the regulation of Dopamine receptor subtypes in the cerebral cortex of the experimental rats. Unilateral stereotaxic single dose infusions of rotenone were administered to the substantia nigra of adult male Wistar rats. Neurotransmitters -serotonin, dopamine and norepinephrine treatments were given to rotenone induced Hemi-Parkinson's rats. Scatchard analysis of Dopamine D1 and D2 receptor showed a significant increase (p < 0.001) in the cerebral cortex of the Parkinson's rats compared to control. These altered parameters were reversed to near control in the serotonin and norepinephrine treated Parkinson's disease rats and no change was observed in Dopamine treated Parkinson's rats. Real-time PCR results confirmed the receptor data. Our results showed serotonin and norepinephrine functionally reversed the Dopamine receptors significantly in rotenone induced Hemi-Parkinson's rat. This has clinical significance in the therapeutic management of Parkinson's disease.

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