Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex

Fuming Zhou, John J. Hablitz

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Dopamine (DA) is an endogenous neuromodulator in the mammalian brain. However, it is still controversial how DA modulates excitability and input- output relations in cortical neurons. It was suggested that DA innervation of dendritic spines regulates glutamatergic inputs to pyramidal neurons, but no experiments were done to test this idea. By recording individual neurons under direct visualization we found that DA enhances inhibitory neuron excitability but decreases pyramidal cell excitability, through depolarization and hyperpolarization, respectively. Accordingly, DA also increased the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs). In the presence of TTX, DA did not affect the frequency, amplitude, or kinetics of miniature IPSCs and excitatory postsynaptic currents in inhibitory interneurons or pyramidal cells. Our results suggest that DA can directly excite cortical interneurons, but there is no detectable DA gate to regulate spontaneous GABA and glutamate release or the properties of postsynaptic GABA and glutamate receptors in neocortical neurons.

Original languageEnglish (US)
Pages (from-to)967-976
Number of pages10
JournalJournal of neurophysiology
Volume81
Issue number3
DOIs
StatePublished - Jan 1 1999

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Synaptic Membranes
Interneurons
Cerebral Cortex
Dopamine
Pyramidal Cells
Neurons
Inhibitory Postsynaptic Potentials
Dendritic Spines
GABA Receptors
Excitatory Postsynaptic Potentials
Glutamate Receptors
gamma-Aminobutyric Acid
Neurotransmitter Agents
Glutamic Acid
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex. / Zhou, Fuming; Hablitz, John J.

In: Journal of neurophysiology, Vol. 81, No. 3, 01.01.1999, p. 967-976.

Research output: Contribution to journalArticle

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