Dopamine receptor subtypes: beyond the D1/D2 classification

Peter H. Andersen, Jay A. Gingrich, Michael D. Bates, Allen Dearry, Pierre Falardeau, Susan Senogles, Marc G. Caron

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

The D1/D2 dopamine receptor classification is widely accepted. However, intense investigative efforts over the last several years using pharmacological, biochemical and behavioral approaches have produced results that are increasingly difficult to reconcile with the existence of only two dopamine receptor subtypes. Recent developments, including cloning of the cDNAs and/ or genes for several members of the large family of G-protein-coupled receptors, have revealed that heterogeneity in the pharmacological or biochemical characteristics of individual receptors often indicates the presence of previously unsuspected molecular subtypes. In this article, Marc Caron and colleagues have assembled the main lines of evidence that suggest the presence of several novel subtypes for both D1 and D2 dopamine receptors and predict that molecular cloning will, in the near future, confirm their existence.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalTrends in Pharmacological Sciences
Volume11
Issue number6
DOIs
StatePublished - Jan 1 1990

Fingerprint

Dopamine D1 Receptors
Dopamine D2 Receptors
Cloning
Dopamine Receptors
Pharmacology
Molecular Cloning
G-Protein-Coupled Receptors
Organism Cloning
Complementary DNA
Genes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

Andersen, P. H., Gingrich, J. A., Bates, M. D., Dearry, A., Falardeau, P., Senogles, S., & Caron, M. G. (1990). Dopamine receptor subtypes: beyond the D1/D2 classification. Trends in Pharmacological Sciences, 11(6), 231-236. https://doi.org/10.1016/0165-6147(90)90249-8

Dopamine receptor subtypes : beyond the D1/D2 classification. / Andersen, Peter H.; Gingrich, Jay A.; Bates, Michael D.; Dearry, Allen; Falardeau, Pierre; Senogles, Susan; Caron, Marc G.

In: Trends in Pharmacological Sciences, Vol. 11, No. 6, 01.01.1990, p. 231-236.

Research output: Contribution to journalArticle

Andersen, PH, Gingrich, JA, Bates, MD, Dearry, A, Falardeau, P, Senogles, S & Caron, MG 1990, 'Dopamine receptor subtypes: beyond the D1/D2 classification', Trends in Pharmacological Sciences, vol. 11, no. 6, pp. 231-236. https://doi.org/10.1016/0165-6147(90)90249-8
Andersen, Peter H. ; Gingrich, Jay A. ; Bates, Michael D. ; Dearry, Allen ; Falardeau, Pierre ; Senogles, Susan ; Caron, Marc G. / Dopamine receptor subtypes : beyond the D1/D2 classification. In: Trends in Pharmacological Sciences. 1990 ; Vol. 11, No. 6. pp. 231-236.
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