Dopaminergic Agonists

Comparative Actions of Amine and Sulfonium Analogues of Dopamine

Akihiko Hamada, Yu An Chang, Norman Uretsky, Duane Miller

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We have investigated the possibility that structural modifications of the sulfonium analogue of dopamine (4) would produce the same pattern of biological activity as structural modifications of dopamine. A series of methyl-tetralinyl-, and naphthalenylsulfonium analogues 5-7 were prepared and tested for their ability to inhibit the potassium-evoked release of [3H]acetylcholine from striatal slices. All compounds were tested under normal conditions and after depletion of dopamine stores with reserpine and α-methyl-p-tyrosine. The amine and sulfonium analogues 2-6 all showed direct agonist activity. The sulfonium analogue 7 produced, predominantly, indirect activity. In contrast to the amine analogues, chemical modifications of the sulfonium compounds produced little change in their dopamine agonist activity.

Original languageEnglish (US)
Pages (from-to)675-680
Number of pages6
JournalJournal of Medicinal Chemistry
Volume27
Issue number5
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Dopamine Agonists
Amines
Dopamine
Sulfonium Compounds
Corpus Striatum
Reserpine
Acetylcholine
Tyrosine
Potassium

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

Dopaminergic Agonists : Comparative Actions of Amine and Sulfonium Analogues of Dopamine. / Hamada, Akihiko; Chang, Yu An; Uretsky, Norman; Miller, Duane.

In: Journal of Medicinal Chemistry, Vol. 27, No. 5, 01.01.1984, p. 675-680.

Research output: Contribution to journalArticle

Hamada, Akihiko ; Chang, Yu An ; Uretsky, Norman ; Miller, Duane. / Dopaminergic Agonists : Comparative Actions of Amine and Sulfonium Analogues of Dopamine. In: Journal of Medicinal Chemistry. 1984 ; Vol. 27, No. 5. pp. 675-680.
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