Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor

Giancarlo Mari, Brian Kirshon, Kenneth J. Moise, Wesley Lee, David B. Cotton

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

To investigate the effects of nifedipine on the human fetal circulation, 11 fetuses whose mothers were treated with nifedipine for treatment of preterm labor were studied. Maximum velocity waveforms were obtained in the middle cerebral artery (n = 8), renal artery (n = 6), ductus arteriosus (n = 8), and umbilical artery (n = 10). Transvalvular maximal velocity waveforms were obtained across the aortic (n = 11) and pulmonary (n = 7) valves. Maternal uterine arteries also were studied (n = 7). Doppler data were collected before and 5 hours after nifedipine therapy. Patients received an oral loading dose of 30 mg of nifedipine followed by a second oral dose of 20 mg 4 hours later. No significant difference in the flow velocity waveforms was found in the vessels studied 5 hours after the initial dose. These results suggest that short-term nifedipine therapy does not influence either fetal or uteroplacental circulation as evaluated with the Doppler technique.

Original languageEnglish (US)
Pages (from-to)1514-1518
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number6 PART 1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Placental Circulation
Premature Obstetric Labor
Nifedipine
Mothers
Therapeutics
Ductus Arteriosus
Uterine Artery
Umbilical Arteries
Middle Cerebral Artery
Renal Artery
Fetus
Lung

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor. / Mari, Giancarlo; Kirshon, Brian; Moise, Kenneth J.; Lee, Wesley; Cotton, David B.

In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 6 PART 1, 01.01.1989, p. 1514-1518.

Research output: Contribution to journalArticle

Mari, Giancarlo ; Kirshon, Brian ; Moise, Kenneth J. ; Lee, Wesley ; Cotton, David B. / Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 161, No. 6 PART 1. pp. 1514-1518.
@article{4abf1e097e474a848ccf079aadc7268c,
title = "Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor",
abstract = "To investigate the effects of nifedipine on the human fetal circulation, 11 fetuses whose mothers were treated with nifedipine for treatment of preterm labor were studied. Maximum velocity waveforms were obtained in the middle cerebral artery (n = 8), renal artery (n = 6), ductus arteriosus (n = 8), and umbilical artery (n = 10). Transvalvular maximal velocity waveforms were obtained across the aortic (n = 11) and pulmonary (n = 7) valves. Maternal uterine arteries also were studied (n = 7). Doppler data were collected before and 5 hours after nifedipine therapy. Patients received an oral loading dose of 30 mg of nifedipine followed by a second oral dose of 20 mg 4 hours later. No significant difference in the flow velocity waveforms was found in the vessels studied 5 hours after the initial dose. These results suggest that short-term nifedipine therapy does not influence either fetal or uteroplacental circulation as evaluated with the Doppler technique.",
author = "Giancarlo Mari and Brian Kirshon and Moise, {Kenneth J.} and Wesley Lee and Cotton, {David B.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0002-9378(89)90915-0",
language = "English (US)",
volume = "161",
pages = "1514--1518",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6 PART 1",

}

TY - JOUR

T1 - Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor

AU - Mari, Giancarlo

AU - Kirshon, Brian

AU - Moise, Kenneth J.

AU - Lee, Wesley

AU - Cotton, David B.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - To investigate the effects of nifedipine on the human fetal circulation, 11 fetuses whose mothers were treated with nifedipine for treatment of preterm labor were studied. Maximum velocity waveforms were obtained in the middle cerebral artery (n = 8), renal artery (n = 6), ductus arteriosus (n = 8), and umbilical artery (n = 10). Transvalvular maximal velocity waveforms were obtained across the aortic (n = 11) and pulmonary (n = 7) valves. Maternal uterine arteries also were studied (n = 7). Doppler data were collected before and 5 hours after nifedipine therapy. Patients received an oral loading dose of 30 mg of nifedipine followed by a second oral dose of 20 mg 4 hours later. No significant difference in the flow velocity waveforms was found in the vessels studied 5 hours after the initial dose. These results suggest that short-term nifedipine therapy does not influence either fetal or uteroplacental circulation as evaluated with the Doppler technique.

AB - To investigate the effects of nifedipine on the human fetal circulation, 11 fetuses whose mothers were treated with nifedipine for treatment of preterm labor were studied. Maximum velocity waveforms were obtained in the middle cerebral artery (n = 8), renal artery (n = 6), ductus arteriosus (n = 8), and umbilical artery (n = 10). Transvalvular maximal velocity waveforms were obtained across the aortic (n = 11) and pulmonary (n = 7) valves. Maternal uterine arteries also were studied (n = 7). Doppler data were collected before and 5 hours after nifedipine therapy. Patients received an oral loading dose of 30 mg of nifedipine followed by a second oral dose of 20 mg 4 hours later. No significant difference in the flow velocity waveforms was found in the vessels studied 5 hours after the initial dose. These results suggest that short-term nifedipine therapy does not influence either fetal or uteroplacental circulation as evaluated with the Doppler technique.

UR - http://www.scopus.com/inward/record.url?scp=0024828467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024828467&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(89)90915-0

DO - 10.1016/0002-9378(89)90915-0

M3 - Article

VL - 161

SP - 1514

EP - 1518

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6 PART 1

ER -