Doppler assessment of the pulsatility index of the middle cerebral artery during constriction of the fetal ductus arteriosus after indomethacin therapy

Giancarlo Mari, Kenneth J. Moise, Russell L. Deter, Brian Kirshon, James C. Huhta, Robert J. Carpenter, David B. Cotton

Research output: Contribution to journalArticle

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Abstract

To investigate the effects of constriction of the ductus arteriosus on the pulsatility index of the middle cerebral artery, maximum velocity waveforms were obtained in 13 fetuses (one set of twins) whose mothers were treated with indomethacin for preterm labor (n = 9) or polyhydramnios (n = 3). Eleven of the fetuses manifested ductal constriction within 48 hours of therapy, whereas two fetuses had constriction after 1 week of therapy. Six of the 13 fetuses also manifested tricuspid insufficiency in association with constriction of the ductus arteriosus. All abnormal cardiac changes resolved in utero after discontinuation of indomethacin. No difference in the pulsatility index values of the middle cerebral artery was observed in the fetuses with ductal constriction but without tricuspid regurgitation (n = 7) when the values were compared with those obtained in absence of ductal constriction (1.87 ± 0.37 vs. 1.88 ± 0.33). In the fetuses that manifested both ductal constriction and tricuspid insufficiency (n = 6), the pulsatility index values in the middle cerebral artery were significantly lower in the presence of ductal constriction when compared with the values obtained in the absence of ductal constriction (2.22 ± 0.26 vs. 1.57 ± 0.34). These results indicate that a response to indomethacin sufficient to cause both ductal constriction and tricuspid insufficiency decreases the pulsatility index of the middle cerebral artery.

Original languageEnglish (US)
Pages (from-to)1528-1531
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number6 PART 1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Ductus Arteriosus
Middle Cerebral Artery
Constriction
Indomethacin
Fetus
Therapeutics
Polyhydramnios
Tricuspid Valve Insufficiency
Premature Obstetric Labor

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Doppler assessment of the pulsatility index of the middle cerebral artery during constriction of the fetal ductus arteriosus after indomethacin therapy. / Mari, Giancarlo; Moise, Kenneth J.; Deter, Russell L.; Kirshon, Brian; Huhta, James C.; Carpenter, Robert J.; Cotton, David B.

In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 6 PART 1, 01.01.1989, p. 1528-1531.

Research output: Contribution to journalArticle

Mari, Giancarlo ; Moise, Kenneth J. ; Deter, Russell L. ; Kirshon, Brian ; Huhta, James C. ; Carpenter, Robert J. ; Cotton, David B. / Doppler assessment of the pulsatility index of the middle cerebral artery during constriction of the fetal ductus arteriosus after indomethacin therapy. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 161, No. 6 PART 1. pp. 1528-1531.
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