Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios

Giancarlo Mari, Kenneth J. Moise, Russell L. Deter, Brian Kirshon, Robert J. Carpenter

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

To investigate the effects of indomethacin on the human fetal renal blood flow velocity waveform, 17 fetuses whose mothers were treated for preterm labor (N=8) or polyhydramnios (N=9) were studied. There were five growth-retarded fetuses (all in the group with polyhydramnios), 11 normal fetuses, and one fetus with red-cell alloimmunization. The indomethacin dose in all patients was 25 mg orally every 6 hours. The gestational age of the fetuses studied varied between 24–35 weeks (mean ± SD 29.6 ± 2.8). The fetal renal artery was studied at its origin from the aorta before and during the first 24 hours of indomethacin therapy. Seven fetuses manifested ductal constriction. Three fetuses also manifested tricuspid regurgitation. All ductal constrictions and the tricuspid regurgitations resolved in utero after discontinuation of indomethacin. There were no significant differences in the pulsatility index values of the renal artery before and during indomethacin therapy. These results suggest that there is no change in fetal renovascular parameters detectable with pulsatility index measurements during the first 24 hours of maternal indomethacin therapy.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalObstetrics and Gynecology
Volume75
Issue number2
StatePublished - 1990
Externally publishedYes

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Polyhydramnios
Blood Flow Velocity
Premature Obstetric Labor
Renal Circulation
Indomethacin
Fetus
Tricuspid Valve Insufficiency
Renal Artery
Constriction
Therapeutics
Mothers
Fetal Blood
Gestational Age
Aorta
Growth

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. / Mari, Giancarlo; Moise, Kenneth J.; Deter, Russell L.; Kirshon, Brian; Carpenter, Robert J.

In: Obstetrics and Gynecology, Vol. 75, No. 2, 1990, p. 199-201.

Research output: Contribution to journalArticle

Mari, Giancarlo ; Moise, Kenneth J. ; Deter, Russell L. ; Kirshon, Brian ; Carpenter, Robert J. / Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. In: Obstetrics and Gynecology. 1990 ; Vol. 75, No. 2. pp. 199-201.
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