Doppler, cardiotocography, and biophysical profile changes in growth-restricted fetuses

Erich Cosmi, Guido Ambrosini, Donato D'Antona, Carlo Saccardi, Giancarlo Mari

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

OBJECTIVE: To assess from diagnosis to delivery the Doppler studies of the umbilical artery, middle cerebral artery, umbilical vein, ductus venosus, and amniotic fluid index of fetuses with idiopathic growth restriction. METHODS: A total of 145 singleton growth-restricted fetuses with abnormal umbilical artery pulsatility indexes were studied. Cesarean delivery was performed because of abnormal biophysical profile or nonreassuring fetal heart rate pattern. RESULTS: There were 4 fetal and 50 neonatal deaths. Two growth-restricted groups were identified: Group A (n = 44) included fetuses in whom all measures became abnormal preceding an abnormal biophysical profile or nonreassuring nonstress test. Group B (n = 101) included fetuses in whom 1 or more measures were normal at the time of cesarean delivery. There was no statistically significant difference in perinatal morbidity and mortality between the 2 groups. Neonatal death was increased in fetuses with umbilical artery reversed flow (odds ratio 2.34, 95% confidence interval 1.16-4.73; P < .05) and ductus venosus reversed flow (odds ratio 4.18, 95% confidence interval 2.01-8.69; P < .05). A significant correlation was also found between low birth weight and adverse perinatal outcome. CONCLUSION: In fetuses with idiopathic growth restriction, 1) low birth weight, 2) umbilical artery reversed flow, and 3) ductus venosus absent or reversed flow are associated with an increased perinatal morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1240-1245
Number of pages6
JournalObstetrics and gynecology
Volume106
Issue number6
DOIs
StatePublished - Jan 1 2005

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Cardiotocography
Umbilical Arteries
Fetus
Growth
Perinatal Mortality
Low Birth Weight Infant
Odds Ratio
Confidence Intervals
Morbidity
Umbilical Veins
Fetal Heart Rate
Middle Cerebral Artery
Amniotic Fluid

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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Doppler, cardiotocography, and biophysical profile changes in growth-restricted fetuses. / Cosmi, Erich; Ambrosini, Guido; D'Antona, Donato; Saccardi, Carlo; Mari, Giancarlo.

In: Obstetrics and gynecology, Vol. 106, No. 6, 01.01.2005, p. 1240-1245.

Research output: Contribution to journalArticle

Cosmi, Erich ; Ambrosini, Guido ; D'Antona, Donato ; Saccardi, Carlo ; Mari, Giancarlo. / Doppler, cardiotocography, and biophysical profile changes in growth-restricted fetuses. In: Obstetrics and gynecology. 2005 ; Vol. 106, No. 6. pp. 1240-1245.
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