Drug interactions with methotrexate

W. E. Evans, Michael Christensen

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

General mechanisms of drug interactions are reviewed, as well as the effects of various drugs on the absorption, distribution, protein binding, eliminations and cellular transport of methotrexate. Published studies demonstrate that prior or concomitant administration of other drugs can alter the efficacy and toxicity of methotrexate. Nonabsorbable antibiotics can decrease methotrexate absorption. Nephrotoxic drugs can decrease methotrexate renal clearance. Salicylates and probenecid may decrease the plasma protein binding and renal tubular secretion of methotrexate. However, the clinical significance of many of these drug interactions is not known or has not been substantiated by extensive clinical observations.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalJournal of Rheumatology
Volume12
Issue number12 SUPPL.
StatePublished - Dec 1 1985
Externally publishedYes

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Drug Interactions
Methotrexate
Protein Binding
Pharmaceutical Preparations
Kidney
Probenecid
Salicylates
Blood Proteins
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Drug interactions with methotrexate. / Evans, W. E.; Christensen, Michael.

In: Journal of Rheumatology, Vol. 12, No. 12 SUPPL., 01.12.1985, p. 15-20.

Research output: Contribution to journalReview article

Evans, WE & Christensen, M 1985, 'Drug interactions with methotrexate', Journal of Rheumatology, vol. 12, no. 12 SUPPL., pp. 15-20.
Evans, W. E. ; Christensen, Michael. / Drug interactions with methotrexate. In: Journal of Rheumatology. 1985 ; Vol. 12, No. 12 SUPPL. pp. 15-20.
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