Dual isotope SPECT imaging of I-123 and I-125

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Peripheral amyloidosis is a debilitating and often fatal disease. SPECT imaging of amyloid in mice has been established using 125I-SAP. Current efforts are aimed at using125I-labeled synthetic peptides such as p5, which are easier to translate into the clinic in the US since SAP is of human origin. It needs to be shown that the new peptide biomarkers correlate well with the gold standard, SAP. As both materials can be radioiodinated using facile chemistry, the challenge then becomes to develop a protocol that supports dual isotope SPECT imaging of 123I-labeled SAP and the 125I-labeled peptide. We address this challenge by first quantifying the amount of cross-talk between the two radio nuclides. We subsequently suggest a correction method.

Original languageEnglish (US)
Title of host publication2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
StatePublished - Jan 1 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

Fingerprint

Single-Photon Emission-Computed Tomography
Isotopes
peptides
isotopes
Peptides
biomarkers
Amyloidosis
nuclides
Radio
Amyloid
mice
Biomarkers
chemistry

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Lee, S., Gregor, J., Osborne, D., & Wall, J. (2013). Dual isotope SPECT imaging of I-123 and I-125. In 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 [6829377] (IEEE Nuclear Science Symposium Conference Record). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829377

Dual isotope SPECT imaging of I-123 and I-125. / Lee, Sanghyeb; Gregor, Jens; Osborne, Dustin; Wall, Jonathan.

2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013. Institute of Electrical and Electronics Engineers Inc., 2013. 6829377 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, S, Gregor, J, Osborne, D & Wall, J 2013, Dual isotope SPECT imaging of I-123 and I-125. in 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013., 6829377, IEEE Nuclear Science Symposium Conference Record, Institute of Electrical and Electronics Engineers Inc., 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013, Seoul, Korea, Republic of, 10/27/13. https://doi.org/10.1109/NSSMIC.2013.6829377
Lee S, Gregor J, Osborne D, Wall J. Dual isotope SPECT imaging of I-123 and I-125. In 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013. Institute of Electrical and Electronics Engineers Inc. 2013. 6829377. (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2013.6829377
Lee, Sanghyeb ; Gregor, Jens ; Osborne, Dustin ; Wall, Jonathan. / Dual isotope SPECT imaging of I-123 and I-125. 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013. Institute of Electrical and Electronics Engineers Inc., 2013. (IEEE Nuclear Science Symposium Conference Record).
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